{"id":"W4406945105","doi":"10.1093/ofid/ofae631.252","title":"P-45. A Phase 3, Randomized Trial Investigating the Safety, Tolerability, and Immunogenicity of V116, an Investigational Adult-Specific Pneumococcal Conjugate Vaccine, in Pneumococcal Vaccine-Naïve Adults 18–64 Years of Age with Increased Risk for Pneumococcal Disease","year":2025,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Immunogenicity; Pneumococcal conjugate vaccine; Tolerability; Streptococcus pneumoniae; Pneumococcal vaccine; Virology; Immunology; Internal medicine; Adverse effect; Antibiotics; Microbiology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00157676,0.001403549,0.001937695,0.0002721561,0.0004162482,0.001097578,0.0006535368,0.00149323,0.006897133],"category_scores_gemma":[0.001710835,0.0006248421,0.001554261,0.0002908433,0.0008995844,0.0009114332,0.0003751205,0.003142603,0.0009949062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005554858,"about_ca_system_score_gemma":0.001326733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008336735,"about_ca_topic_score_gemma":0.001840011,"domain_scores_codex":[0.9993957,0.0003112857,0.00003356289,0.0001211781,0.0000464366,0.00009178485],"domain_scores_gemma":[0.99926,0.0001625596,0.0001930125,0.00004918301,0.00005866043,0.000276658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9739682,0.006016674,0.0007991943,0.0007555053,0.0009842269,0.00004703109,0.00005092228,0.000365397,0.003219426,0.0001961568,0.001020133,0.01257716],"study_design_scores_gemma":[0.9224151,0.07349636,0.001824209,0.00004187478,0.0004452897,0.00003810227,0.00001653124,0.0004106497,0.0003561602,0.0002118868,0.0007334651,0.00001030369],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743276,0.005351156,0.001115821,0.0007338012,0.0006615447,0.01048047,0.002439084,0.000231936,0.00465861],"genre_scores_gemma":[0.9813095,0.002196806,0.001788857,0.001335304,0.0002966125,0.008530643,0.001505469,0.00002903906,0.003007825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006897133,"threshold_uncertainty_score":0.0230732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351296291896855,"score_gpt":0.3036400316090577,"score_spread":0.2901270686900892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}