{"id":"W4406950201","doi":"10.1093/ofid/ofae631.004","title":"167. Phase 3, Randomized, Controlled Trial Evaluating Safety, Efficacy, and Pharmacokinetics (PK) of Clesrovimab in Infants and Children at Increased Risk for Severe Respiratory Syncytial Virus (RSV) Disease","year":2025,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Respiratory viral infections research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Sanofi K.K.; National Institutes of Health; Moderna; Mitsubishi Tanabe Pharma Corporation; AstraZeneca; Bill and Melinda Gates Foundation; Pfizer; Pfizer Japan; Novavax; Gilead Sciences; Sanofi","keywords":"Medicine; Pharmacokinetics; Randomized controlled trial; Disease; Pediatrics; Virus; Virology; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002372546,0.001485078,0.003015776,0.0004352196,0.0004930722,0.001118278,0.0007511124,0.002089811,0.01115303],"category_scores_gemma":[0.002430122,0.000782155,0.002003191,0.0003741097,0.0007621308,0.0008490224,0.0003309033,0.002740873,0.001731168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007896737,"about_ca_system_score_gemma":0.00211629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008408281,"about_ca_topic_score_gemma":0.002669126,"domain_scores_codex":[0.9988907,0.0006323673,0.00007793907,0.0001644008,0.00007605103,0.0001584329],"domain_scores_gemma":[0.9988303,0.0003073557,0.0003373853,0.00009840624,0.0001063712,0.000320201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9811847,0.003502704,0.0004529459,0.0005831847,0.0005019507,0.00003528045,0.00003413419,0.0002672223,0.002404679,0.0001345213,0.001340159,0.009558572],"study_design_scores_gemma":[0.9618614,0.03590164,0.0008494866,0.00002513615,0.0001878349,0.00001990247,0.000007370405,0.0002276555,0.0002131873,0.000101391,0.0005978604,0.000007141816],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9331172,0.006975872,0.002531298,0.001920548,0.001350058,0.03744505,0.009244138,0.0006086472,0.006807148],"genre_scores_gemma":[0.9390968,0.002297733,0.006651766,0.003118899,0.000648129,0.03868566,0.004017921,0.00006764208,0.005415548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01115303,"threshold_uncertainty_score":0.03731066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251608760164245,"score_gpt":0.4055027074658137,"score_spread":0.3829866198641713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}