{"id":"W4406950201","doi":"10.1093/ofid/ofae631.004","title":"167. Phase 3, Randomized, Controlled Trial Evaluating Safety, Efficacy, and Pharmacokinetics (PK) of Clesrovimab in Infants and Children at Increased Risk for Severe Respiratory Syncytial Virus (RSV) Disease","year":2025,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Respiratory viral infections research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Sanofi K.K.; National Institutes of Health; Moderna; Mitsubishi Tanabe Pharma Corporation; AstraZeneca; Bill and Melinda Gates Foundation; Pfizer; Pfizer Japan; Novavax; Gilead Sciences; Sanofi","keywords":"Medicine; Pharmacokinetics; Randomized controlled trial; Disease; Pediatrics; Virus; Virology; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002462515,0.000443994,0.002188787,0.0007283781,0.0005384571,0.0001705492,0.0002315363,0.0001523265,0.0001366299],"category_scores_gemma":[0.01142247,0.0003718878,0.0003969781,0.0005200846,0.0005548699,0.0003142755,0.0006651352,0.0003345745,0.000004770076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002838967,"about_ca_system_score_gemma":0.001068295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000794284,"about_ca_topic_score_gemma":0.0002487462,"domain_scores_codex":[0.995257,0.001537462,0.001429786,0.000742543,0.0004920693,0.000541128],"domain_scores_gemma":[0.9949532,0.003109909,0.0005459,0.0005329063,0.0003359508,0.0005221354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8351724,0.002347231,0.1479533,0.0001833777,0.00088363,0.00001281473,0.00002525443,0.0001153643,0.0007170021,0.0001396356,0.0005632132,0.01188677],"study_design_scores_gemma":[0.9401354,0.002934802,0.04883229,0.0003364906,0.002834945,0.000007915215,0.00001671651,0.00334135,0.0004407225,0.0005522085,0.0002427317,0.0003244736],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676342,0.003406482,0.00009918365,0.0001136963,0.0002086301,0.02642955,0.0008220426,0.00006535856,0.001220857],"genre_scores_gemma":[0.995425,0.0006587031,0.00003759115,0.0005561671,0.0001260813,0.002863551,0.0001319314,0.00005383025,0.0001471287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.104963,"threshold_uncertainty_score":0.9998733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251608760164245,"score_gpt":0.4055027074658137,"score_spread":0.3829866198641713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}