{"id":"W4406954776","doi":"10.1093/ofid/ofae631.247","title":"P-40. Impact of case and control selection on influenza vaccine effectiveness (VE) among adults aged 40 years and older hospitalized with acute respiratory illness (ARI) during 2022-2023 using a test negative design (TND): secondary analysis of the North America multi-specimen study","year":2025,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada); Toronto Public Health; Health Sciences Centre; University of Toronto; North York General Hospital; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Respiratory illness; Influenza vaccine; Test (biology); Respiratory system; Intensive care medicine; Pediatrics; Internal medicine; Gerontology; Vaccination; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04209862,0.0008256076,0.0009428153,0.001159887,0.0006410268,0.001542294,0.002181024,0.00136524,0.004558967],"category_scores_gemma":[0.06897173,0.000577552,0.00560139,0.001396161,0.001259065,0.001304097,0.001261757,0.00128699,0.0003961003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006428849,"about_ca_system_score_gemma":0.0008103579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005484776,"about_ca_topic_score_gemma":0.003288047,"domain_scores_codex":[0.9167272,0.06113026,0.004644617,0.01026844,0.005519718,0.001709698],"domain_scores_gemma":[0.9371502,0.04325233,0.008527577,0.007773212,0.001846012,0.00145059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005380824,0.0002200243,0.9749703,0.0002366699,0.01119046,0.0002495538,0.0002155985,0.0006205523,0.0007237183,0.0004375551,0.001110025,0.004644565],"study_design_scores_gemma":[0.0006426022,0.003975302,0.9744443,0.00010515,0.004770059,0.0004890707,0.0002686855,0.01140478,0.0008429878,0.0005639744,0.002463183,0.000029907],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803137,0.002415224,0.009578311,0.0004039371,0.0003502518,0.0004801544,0.003996724,0.00007851346,0.002383237],"genre_scores_gemma":[0.996843,0.00005803923,0.001262891,0.0001409382,0.00006240809,0.0003124013,0.0009043766,0.00002189867,0.0003940932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04209862,"threshold_uncertainty_score":0.2226415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01630745994962979,"score_gpt":0.3428792539860365,"score_spread":0.3265717940364067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}