{"id":"W4406955518","doi":"10.1093/ofid/ofae631.325","title":"P-118. Patient Reported Outcomes (PRO) Analysis of the Phase 2 Multi-Center, Prospective, Randomized, Double-Blind Study Assessing Nitazoxanide for the Treatment of Norovirus in Hematopoietic Stem Cell and Solid Organ Transplant Recipients","year":2025,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Norovirus; Nitazoxanide; Hematopoietic stem cell; Hematopoietic stem cell transplantation; Internal medicine; Solid organ; Oncology; Stem cell; Haematopoiesis; Virology; Transplantation; Organ transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0028763,0.001232593,0.001896616,0.0004262107,0.000334695,0.000708961,0.0004985297,0.00111812,0.006486465],"category_scores_gemma":[0.002209881,0.0005427579,0.001302548,0.0003439962,0.0009022644,0.0006700142,0.0003491151,0.001969228,0.0005735994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003439093,"about_ca_system_score_gemma":0.0007704697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002298144,"about_ca_topic_score_gemma":0.0004370104,"domain_scores_codex":[0.9977233,0.001696601,0.0001278232,0.0001634808,0.0001543198,0.0001345285],"domain_scores_gemma":[0.998255,0.0005812607,0.0004695692,0.0001341061,0.0001136106,0.0004464295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9785354,0.006231006,0.001693362,0.0004055763,0.0006181779,0.0000295986,0.00002073926,0.0001730776,0.004168805,0.00006714588,0.000407729,0.007649368],"study_design_scores_gemma":[0.8490059,0.1417296,0.007166535,0.00002078549,0.0003245955,0.00002483031,0.00001031355,0.0004612512,0.0007753983,0.00005903846,0.0004115563,0.0000102261],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867331,0.00166345,0.0009821452,0.0002940788,0.0002702531,0.006539008,0.00176043,0.00008977744,0.001667647],"genre_scores_gemma":[0.9867137,0.0006487035,0.001804473,0.0004501117,0.0002573396,0.007368545,0.001085105,0.00001526389,0.001656591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006486465,"threshold_uncertainty_score":0.02169943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03144612410226873,"score_gpt":0.371722879444072,"score_spread":0.3402767553418032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}