{"id":"W4406958478","doi":"10.1007/s11538-025-01413-5","title":"Adaptive Immunity Determines the Cancer Treatment Outcome of Oncolytic Virus and Anti-PD-1","year":2025,"lang":"en","type":"article","venue":"Bulletin of Mathematical Biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Oncolytic virus; Immunity; Virus; Cancer; Acquired immune system; Virology; Immune system; Medicine; Outcome (game theory); Cancer treatment; Immunology; Biology; Internal medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003062542,0.0001251166,0.0002320592,0.0001720642,0.00009620447,0.0004291502,0.000149446,0.0002647606,0.001329713],"category_scores_gemma":[0.0006532366,0.00009108086,0.0001852441,0.0001027813,0.0002315526,0.0002517116,0.0001633215,0.0006295923,0.0001651426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002695963,"about_ca_system_score_gemma":0.0002304048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000139263,"about_ca_topic_score_gemma":0.0001225197,"domain_scores_codex":[0.9998304,0.0000475495,0.000008293608,0.0000309256,0.0000236431,0.00005917626],"domain_scores_gemma":[0.9997591,0.00009132856,0.00006364061,0.00001945688,0.00002318959,0.00004323628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00755074,0.001060462,0.06209888,0.0001610542,0.0001289231,0.0002375591,0.000184155,0.004714566,0.84647,0.004789269,0.0007031916,0.07190114],"study_design_scores_gemma":[0.0007535212,0.01507369,0.3883286,0.00006420763,0.0008153818,0.002450767,0.000535836,0.0470199,0.5246421,0.01059136,0.009651464,0.00007333216],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970401,0.0009598673,0.0009036647,0.0001094454,0.00002061829,0.000009970241,0.00003613657,0.00001134581,0.0009089344],"genre_scores_gemma":[0.9993624,0.0001724044,0.0001428655,0.00002747237,0.00001083767,0.00000635816,0.00002586699,0.000002727698,0.0002490656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329713,"threshold_uncertainty_score":0.004448354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03667225144235619,"score_gpt":0.3569710615211025,"score_spread":0.3202988100787463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}