{"id":"W4406958600","doi":"10.1097/aln.0000000000005397","title":"Tranexamic Dosing for Major Joint Arthroplasty in Adult Patients with Chronic Kidney Disease: A Pharmacokinetic Study and New Dosing Regimen","year":2025,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Blood transfusion and management","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto","funders":"","keywords":"Medicine; Tranexamic acid; Kidney disease; Renal function; Dosing; Population; Anesthesia; Pharmacokinetics; Regimen; Surgery; Bolus (digestion); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000961768,0.0001748125,0.0003480375,0.0002006149,0.00006672366,0.00001078777,0.00004540261,0.00004783598,0.00003379896],"category_scores_gemma":[0.000036938,0.0001331635,0.00003705685,0.0001719167,0.00006590144,0.00003778542,0.00002047243,0.0001172636,0.000002372156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005122988,"about_ca_system_score_gemma":0.000199036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000156319,"about_ca_topic_score_gemma":0.0001447884,"domain_scores_codex":[0.9989199,0.00006833003,0.0002475127,0.0003931897,0.00009481185,0.0002762432],"domain_scores_gemma":[0.9994813,0.00004773712,0.00004479378,0.0001925607,0.00004265889,0.0001909157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006388101,0.00226636,0.888801,0.001023607,0.0003469324,0.0002328193,0.001249674,0.00001945392,0.001274146,0.0003441515,0.002782107,0.09527168],"study_design_scores_gemma":[0.02864691,0.002109571,0.9622899,0.0005018726,0.0005825114,0.000006980109,0.0001458793,0.0002007564,0.0001281642,0.00007011631,0.005164233,0.0001531298],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941155,0.0004824565,0.0002350797,0.002313321,0.00008054455,0.00265861,0.000002564837,0.00004186073,0.00007007853],"genre_scores_gemma":[0.9957671,0.0001360192,0.0002444467,0.003271525,0.00003756983,0.0001284992,0.00002892237,0.00001894112,0.0003670158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09511855,"threshold_uncertainty_score":0.5430248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01205287276454369,"score_gpt":0.2591580062599695,"score_spread":0.2471051334954258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}