{"id":"W4406969198","doi":"10.1172/jci187024","title":"Elevated protein lactylation promotes immunosuppressive microenvironment and therapeutic resistance in pancreatic ductal adenocarcinoma","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"National Natural Science Foundation of China","keywords":"Pancreatic ductal adenocarcinoma; Cancer research; Tumor microenvironment; Adenocarcinoma; Medicine; Biology; Pancreatic cancer; Internal medicine; Immunology; Cancer; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178117,0.0001435108,0.000194054,0.0002057189,0.0001341516,0.0004085316,0.00007405985,0.0002021125,0.0009372904],"category_scores_gemma":[0.000129776,0.0001019688,0.0001988732,0.0002183001,0.0001759911,0.0001557668,0.0002055685,0.0004071924,0.0002148509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002551037,"about_ca_system_score_gemma":0.0001302155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002195666,"about_ca_topic_score_gemma":0.0002098667,"domain_scores_codex":[0.9999133,0.00001525569,0.00001053041,0.0000165054,0.0000222723,0.00002214573],"domain_scores_gemma":[0.99989,0.00001190865,0.00003777532,0.00001232416,0.000009363986,0.00003862488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001077555,0.0001409491,0.01395581,0.0000660122,0.00002212868,0.0006317776,0.00005619763,0.000187381,0.9769706,0.0001253707,0.0001472131,0.006619079],"study_design_scores_gemma":[0.0001446455,0.002883773,0.2973408,0.0000226488,0.0001308633,0.006869585,0.0005088417,0.003992944,0.6769711,0.0004492872,0.01065735,0.00002817243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983848,0.0007207659,0.0002817216,0.000042847,0.000005857728,0.0000065641,0.00004893366,0.00003039626,0.0004781146],"genre_scores_gemma":[0.9991,0.0003191919,0.0001102713,0.00002067915,0.000002831567,0.000006193641,0.00007119309,0.000004230961,0.0003653633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009372904,"threshold_uncertainty_score":0.003135502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03386812966126453,"score_gpt":0.3307217101070681,"score_spread":0.2968535804458036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}