{"id":"W4406971474","doi":"10.2196/58031","title":"Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial","year":2025,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Risperidone; Tolerability; Clinical Global Impression; Autism spectrum disorder; Atypical antipsychotic; Autism; Childhood Autism Rating Scale; Lethargy; Aripiprazole; Psychiatry; Irritability; Medicine; Clozapine; Psychology; Clinical trial; Pediatrics; Clinical psychology; Antipsychotic; Adverse effect; Schizophrenia (object-oriented programming); Anxiety; Internal medicine; Placebo","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01524322,0.004921681,0.008469864,0.001577666,0.003189769,0.002942564,0.003896134,0.005577806,0.04882911],"category_scores_gemma":[0.01335711,0.002239987,0.004520162,0.001851664,0.002744808,0.002739902,0.001669779,0.006692848,0.0123599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003727242,"about_ca_system_score_gemma":0.01641621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001986925,"about_ca_topic_score_gemma":0.005219188,"domain_scores_codex":[0.9931986,0.003367853,0.0007641062,0.0009693974,0.0007268609,0.0009731847],"domain_scores_gemma":[0.9918972,0.001212351,0.00157776,0.001141322,0.002368553,0.001802829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8991364,0.03199999,0.00103894,0.0117687,0.001291252,0.0003357621,0.0003740633,0.00200064,0.005297851,0.002224355,0.01208934,0.03244267],"study_design_scores_gemma":[0.9021865,0.0608681,0.002640813,0.001772273,0.0007770126,0.0001037514,0.0001334906,0.001017743,0.0009685875,0.001110988,0.02832521,0.00009544539],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.006580307,0.0005568718,0.001130795,0.0002091366,0.0002890412,0.9881429,0.001687152,0.00009545429,0.001308327],"genre_scores_gemma":[0.007115899,0.0004729161,0.001922232,0.0002541081,0.0001099416,0.9886574,0.000554238,0.000009209021,0.0009040584],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04882911,"threshold_uncertainty_score":0.1633496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3149744269708196,"score_gpt":0.5779915946095902,"score_spread":0.2630171676387705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}