{"id":"W4406986947","doi":"10.1371/journal.pbio.3003022","title":"Pilin antigenic variants impact gonococcal lifestyle and antibiotic tolerance by modulating interbacterial forces","year":2025,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Deutsche Forschungsgemeinschaft; Center for Molecular Medicine Cologne, University of Cologne; Helmholtz-Gemeinschaft","keywords":"Pilin; Biology; Pilus; Microbiology; Fimbriae Proteins; Biofilm; Phase variation; Population; Antigenic variation; Virulence; Neisseria gonorrhoeae; Fimbria; Antigen; Bacteria; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033267,0.0002172,0.0001563447,0.0001353233,0.00009704422,0.000340224,0.0001421815,0.00023863,0.000698078],"category_scores_gemma":[0.0002772802,0.0001464134,0.0001233751,0.0001125587,0.0002604023,0.0001495198,0.0002461148,0.0002333923,0.00007627249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001848986,"about_ca_system_score_gemma":0.0001723065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008347558,"about_ca_topic_score_gemma":0.001058796,"domain_scores_codex":[0.999838,0.00003573534,0.00001353435,0.00002945158,0.00004034624,0.00004284742],"domain_scores_gemma":[0.9998624,0.00002867518,0.00004759622,0.00001478802,0.00001236491,0.00003409083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001355163,0.00002384855,0.002063903,0.00001124609,0.000007498478,0.00002368432,0.00001527093,0.00008105666,0.9966643,0.00003814479,0.00001012896,0.000925303],"study_design_scores_gemma":[0.00002961828,0.0005835598,0.1037519,0.000006130185,0.00005150644,0.0002881862,0.0001436483,0.003450743,0.8908526,0.0001419132,0.0006800062,0.000020118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995987,0.00006868842,0.000161426,0.00001493521,0.000001386486,0.00000214482,0.00003135968,0.000005647179,0.0001156483],"genre_scores_gemma":[0.9995694,0.00003826582,0.0002369985,0.00001482237,7.062332e-7,0.000002366252,0.00002825573,0.0000046163,0.0001046253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008347558,"threshold_uncertainty_score":0.00233537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004979849482230848,"score_gpt":0.2511779277365639,"score_spread":0.246198078254333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}