{"id":"W4406986947","doi":"10.1371/journal.pbio.3003022","title":"Pilin antigenic variants impact gonococcal lifestyle and antibiotic tolerance by modulating interbacterial forces","year":2025,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Deutsche Forschungsgemeinschaft; Center for Molecular Medicine Cologne, University of Cologne; Helmholtz-Gemeinschaft","keywords":"Pilin; Biology; Pilus; Microbiology; Fimbriae Proteins; Biofilm; Phase variation; Population; Antigenic variation; Virulence; Neisseria gonorrhoeae; Fimbria; Antigen; Bacteria; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000503856,0.0001645118,0.0002001176,0.00002764317,0.00006982787,0.00002728661,0.0001280282,0.0002534546,0.00001912806],"category_scores_gemma":[0.00009135249,0.0001312384,0.00005445397,0.00007050818,0.0001111386,0.000006333318,0.0001317518,0.00008729767,0.000002180624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009798225,"about_ca_system_score_gemma":0.00002622444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000199126,"about_ca_topic_score_gemma":0.000003410402,"domain_scores_codex":[0.9990879,0.00005977919,0.0002109223,0.0003828848,0.00002191188,0.0002366496],"domain_scores_gemma":[0.9996637,0.00001501246,0.00006931612,0.0001592983,0.00003785633,0.00005478805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001221329,0.00002478343,0.03864994,0.00002347205,0.00006139846,2.008603e-7,0.00001093145,7.972284e-7,0.9584197,0.00003732289,0.0001471211,0.002502189],"study_design_scores_gemma":[0.0006140076,0.0003102181,0.07459111,0.00003849151,0.00002267688,0.00000861636,0.000006859001,0.0009575369,0.9221024,0.0001855748,0.0009418094,0.0002207399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982548,0.0005250923,0.0005023947,0.0001295796,0.0002054914,0.0001363687,0.00009385266,0.00001710044,0.0001353525],"genre_scores_gemma":[0.9984697,0.0001466587,0.0001886404,0.0002414594,0.0002053865,0.000003954886,0.0006026875,0.000009177181,0.0001323325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03631735,"threshold_uncertainty_score":0.5351747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004979849482230848,"score_gpt":0.2511779277365639,"score_spread":0.246198078254333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}