{"id":"W4406988344","doi":"10.1093/cid/ciaf043","title":"A Pilot, Randomized Controlled Trial of Dual Daily HIV and Sexually Transmitted Infection Pre-exposure Prophylaxis Using Tenofovir Disoproxil Fumarate/Emtricitabine and Doxycycline in Gay, Bisexual, and Other Men Who Have Sex With Men and Transgender Women: The DuDHS Study","year":2025,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Providence Health Care; BC Centre for Disease Control; Ottawa Hospital; University of British Columbia","funders":"","keywords":"Medicine; Emtricitabine; Doxycycline; Pre-exposure prophylaxis; Human immunodeficiency virus (HIV); Men who have sex with men; Tenofovir; Randomized controlled trial; Gynecology; Virology; Internal medicine; Viral load; Syphilis; Antiretroviral therapy; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002661834,0.001771559,0.003336473,0.0004548307,0.0006085041,0.001130502,0.001336802,0.00193263,0.008055747],"category_scores_gemma":[0.002756347,0.0008225839,0.001630317,0.0003263493,0.001625385,0.001209154,0.000671972,0.00312508,0.0009691673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007422659,"about_ca_system_score_gemma":0.001713038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001821139,"about_ca_topic_score_gemma":0.003275097,"domain_scores_codex":[0.9987955,0.0006680003,0.00008635086,0.0001884979,0.00006685072,0.0001948368],"domain_scores_gemma":[0.9977916,0.0005689941,0.0004255476,0.000200391,0.0001726224,0.0008407814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9810101,0.01303964,0.0003249413,0.0002269248,0.0003152288,0.00001763434,0.00003942527,0.00009092244,0.0005566786,0.00004213232,0.0002347316,0.004101503],"study_design_scores_gemma":[0.9273169,0.07129753,0.000834176,0.0000138,0.0001241699,0.000009068185,0.00001709074,0.00012571,0.00008320908,0.00004323682,0.0001304785,0.000004627576],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989813,0.001203363,0.0003537362,0.0003946939,0.0005275204,0.005820616,0.0006886853,0.00009178968,0.001106537],"genre_scores_gemma":[0.9858227,0.0008617202,0.00161715,0.0006001843,0.0004236181,0.007886851,0.0006262162,0.00001173185,0.002149747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008055747,"threshold_uncertainty_score":0.02694917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0359072289949981,"score_gpt":0.3801156749465501,"score_spread":0.344208445951552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}