{"id":"W4406992568","doi":"10.1161/str.56.suppl_1.89","title":"Abstract 89: A first-in-class humanized antibody fragment targeting platelet glycoprotein Ibα: a comprehensive preclinical study of CA1001 for the treatment of acute ischemic stroke","year":2025,"lang":"en","type":"article","venue":"Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital; iCo Therapeutics (Canada)","funders":"","keywords":"Medicine; Stroke (engine); Ischemic stroke; Platelet; Antibody; Platelet membrane glycoprotein; Immunology; P-glycoprotein; Pharmacology; Ischemia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040095,0.000937525,0.0005174152,0.0005403177,0.0001846151,0.0003428822,0.0004746916,0.0005387443,0.001586431],"category_scores_gemma":[0.0002001207,0.0002168941,0.000388176,0.0003134215,0.0002494246,0.0002267342,0.0001704188,0.001126071,0.0006963209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004155144,"about_ca_system_score_gemma":0.0006803744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132423,"about_ca_topic_score_gemma":0.001226153,"domain_scores_codex":[0.9998716,0.0000221776,0.000007529391,0.00002107288,0.00003714755,0.00004047991],"domain_scores_gemma":[0.9999117,0.00000876644,0.00001715622,0.00001014296,0.00001741328,0.000034893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002244519,0.003276257,0.00036961,0.0002745564,0.0001132516,0.0002893369,0.00006812203,0.0007644841,0.9662595,0.0002587255,0.001754965,0.02432672],"study_design_scores_gemma":[0.004353283,0.05333029,0.008189092,0.00007590096,0.0006137855,0.002428336,0.00004321482,0.002977622,0.8993852,0.0002288845,0.02833825,0.00003616578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801002,0.006726497,0.00575337,0.0005584907,0.0001462306,0.000926194,0.00133373,0.0002390929,0.004216218],"genre_scores_gemma":[0.9731104,0.009667155,0.004986056,0.0004666579,0.00007577448,0.0005997449,0.004461265,0.00005573944,0.006577148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001586431,"threshold_uncertainty_score":0.005307138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02622431518885407,"score_gpt":0.3406000712240293,"score_spread":0.3143757560351752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}