{"id":"W4406994064","doi":"10.1161/str.56.suppl_1.141","title":"Abstract 141: Clinical Trial Emulation Leveraging Genetic Effects: A Proof-of-Concept Application to SPRINT","year":2025,"lang":"en","type":"article","venue":"Stroke","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Proof of concept; Sprint; Emulation; Clinical trial; Physical medicine and rehabilitation; Physical therapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1141882,0.002031995,0.002026369,0.0009761894,0.0006752425,0.002621161,0.002252282,0.004109926,0.01802811],"category_scores_gemma":[0.2485043,0.001062647,0.004940875,0.0008527466,0.00229687,0.001799485,0.002593172,0.003982646,0.00231029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001350707,"about_ca_system_score_gemma":0.005610859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004477124,"about_ca_topic_score_gemma":0.0005019748,"domain_scores_codex":[0.9010992,0.08911023,0.002277762,0.002503473,0.004429495,0.0005798966],"domain_scores_gemma":[0.7888233,0.1756869,0.01291734,0.0132078,0.006913552,0.002451161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.07707909,0.008832376,0.01253525,0.02759582,0.01684249,0.001450582,0.001715785,0.0643412,0.02036528,0.103046,0.05869531,0.6075009],"study_design_scores_gemma":[0.2546659,0.1114996,0.01222748,0.01319273,0.01994519,0.002197064,0.0003857683,0.1860548,0.03487058,0.1585899,0.2057914,0.0005796163],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.07458773,0.008010527,0.7933874,0.01373706,0.005210897,0.07224803,0.00789836,0.005977534,0.01894249],"genre_scores_gemma":[0.2298953,0.002049351,0.6782072,0.00659935,0.001106811,0.07748412,0.001432092,0.0004795954,0.002746211],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.1141882,"threshold_uncertainty_score":0.6038921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539513769954765,"score_gpt":0.3226215297181872,"score_spread":0.3072263920186395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}