{"id":"W4407002105","doi":"10.3389/fnmol.2025.1542938","title":"Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes","year":2025,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Agence Nationale de la Recherche","keywords":"Microglia; Cell biology; Biology; Peroxisome; Oxidative stress; Reactive oxygen species; Neuroinflammation; Inflammation; Oligodendrocyte; Neuroscience; Central nervous system; Immunology; Myelin; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294022,0.0004115168,0.00032488,0.000218664,0.0002078524,0.000317091,0.0001114392,0.0003011393,0.0005725701],"category_scores_gemma":[0.0001080411,0.00012753,0.0003009938,0.0001374402,0.000224312,0.0001630242,0.000246058,0.0004398429,0.0002203457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000184979,"about_ca_system_score_gemma":0.0001537208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003315639,"about_ca_topic_score_gemma":0.0004469535,"domain_scores_codex":[0.9998,0.00003040317,0.00001916976,0.00003604992,0.00004975321,0.00006467973],"domain_scores_gemma":[0.9999055,0.000008380563,0.00003428676,0.00001040429,0.00001486564,0.00002654617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001654087,0.00001254394,0.0004419622,0.00002952086,0.000006788114,0.0001147765,0.00001699248,0.00001406571,0.9987819,0.00001947447,0.00001166758,0.0003849732],"study_design_scores_gemma":[0.00001952632,0.0004458267,0.03536022,0.00002863588,0.00004762251,0.001067415,0.0002568435,0.0004281957,0.9606299,0.0002306421,0.001474833,0.00001033263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972801,0.001189342,0.0007744952,0.00008743641,0.00001925,0.00001164369,0.0002014173,0.00002152676,0.0004147266],"genre_scores_gemma":[0.9964874,0.001359367,0.0007651506,0.00008676087,0.00001400737,0.00003565005,0.0003693598,0.000008981086,0.000873363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005725701,"threshold_uncertainty_score":0.001915395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005423183126817234,"score_gpt":0.2374258251622772,"score_spread":0.23200264203546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}