{"id":"W4407002276","doi":"10.1002/alz.14467","title":"The higher benefit of lecanemab in males compared to females in CLARITY AD is probably due to a real sex effect","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Baycrest Hospital; University of Toronto; Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; Canadian Institutes of Health Research; Fondation Brain Canada; McGill University","keywords":"CLARITY; Significant difference; Cognition; Demography; Medicine; Disease; Subgroup analysis; Cohort; Psychology; Clinical psychology; Internal medicine; Psychiatry; Biology; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006805549,0.0004232454,0.001084301,0.0002150105,0.000303206,0.0006758786,0.0003933575,0.000804527,0.02240404],"category_scores_gemma":[0.01607344,0.0002309964,0.003158136,0.0001622662,0.0005753548,0.0007652846,0.0003259286,0.001274659,0.001183838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006396238,"about_ca_system_score_gemma":0.0009062975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001443434,"about_ca_topic_score_gemma":0.001712183,"domain_scores_codex":[0.9977669,0.001366072,0.0001270531,0.0004333844,0.0001856728,0.0001209893],"domain_scores_gemma":[0.9915736,0.006378169,0.0008463904,0.0006989354,0.0002733888,0.00022944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1421461,0.001383493,0.2448337,0.007553063,0.0171276,0.001732422,0.0006691566,0.06736603,0.02921817,0.04218325,0.03399036,0.4117967],"study_design_scores_gemma":[0.06421337,0.07388803,0.3591995,0.003527831,0.03515936,0.006494622,0.0009956493,0.1227137,0.04639092,0.1486246,0.1382698,0.0005226425],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.8885053,0.01509262,0.03855021,0.008405333,0.001103487,0.001198363,0.00899497,0.0005437615,0.03760606],"genre_scores_gemma":[0.9892629,0.0009370515,0.004466547,0.001951555,0.00008604098,0.0003226843,0.0008836082,0.00006296549,0.0020266],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.02240404,"threshold_uncertainty_score":0.07494903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03080309717077807,"score_gpt":0.3415727281549387,"score_spread":0.3107696309841607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}