{"id":"W4407021913","doi":"10.1038/s41467-024-55665-1","title":"Proteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Queen's University; University of British Columbia","funders":"Deutsche Forschungsgemeinschaft; Cancer Research Society","keywords":"Chemotherapy; Bladder cancer; Cisplatin; Biology; Cancer research; Medicine; Computational biology; Bioinformatics; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285828,0.0001502439,0.0002536171,0.0004470575,0.00020939,0.0004381679,0.0001036527,0.0002484342,0.0007030663],"category_scores_gemma":[0.0002795401,0.000117805,0.0002278269,0.0004304469,0.0001345431,0.0002068352,0.0002749109,0.0002439468,0.0002189006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001765471,"about_ca_system_score_gemma":0.0001800725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005614892,"about_ca_topic_score_gemma":0.0009775967,"domain_scores_codex":[0.9999053,0.00001115898,0.000008626164,0.00002145287,0.0000302995,0.00002312439],"domain_scores_gemma":[0.9998914,0.00001348806,0.00003319022,0.000008642331,0.00002768763,0.00002571538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005575381,0.00003227917,0.03444328,0.0001379287,0.00006171287,0.0002133768,0.000144302,0.0001563214,0.9572829,0.00005915103,0.0002330986,0.00667811],"study_design_scores_gemma":[0.000008911681,0.0003250223,0.8635033,0.00002406482,0.00008524197,0.001488243,0.0004288942,0.001180623,0.1303094,0.0001239601,0.002506691,0.00001549037],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967124,0.001245302,0.0006160571,0.0000651073,0.000009616945,0.00001479656,0.0006364873,0.00002334179,0.0006767258],"genre_scores_gemma":[0.9945464,0.001306827,0.001497668,0.00007882032,0.000009826374,0.00002970791,0.001513103,0.00001122173,0.001006376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007030663,"threshold_uncertainty_score":0.002351999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194340221957146,"score_gpt":0.3459389955826617,"score_spread":0.3265049733869471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}