{"id":"W4407027692","doi":"10.1101/2025.01.28.635126","title":"Mutations in SOD1 induce ALS-related phenotypes in 3D iPSC-derived motor neuron (MN) spheroids","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Health Canada; Montreal Neurological Institute and Hospital","funders":"Québec Consortium for Drug Discovery","keywords":"SOD1; Phenotype; Spheroid; Biology; Amyotrophic lateral sclerosis; Hypoactivity; Mutant; Mutation; Genetics; Protein subunit; Gene; Cell biology; Cell culture; Disease; Neuroscience; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002477747,0.00030049,0.0003761893,0.0002318395,0.0001811148,0.000376189,0.0001557299,0.0004615396,0.0007838783],"category_scores_gemma":[0.0002045159,0.0001660575,0.0003554179,0.0001771842,0.0002209939,0.0001542041,0.0003389137,0.0006997688,0.0008653002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768006,"about_ca_system_score_gemma":0.0001739507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008930699,"about_ca_topic_score_gemma":0.001245985,"domain_scores_codex":[0.9997911,0.00002384836,0.0000402619,0.00004564447,0.00007497634,0.00002417492],"domain_scores_gemma":[0.9997997,0.00006343843,0.00003880088,0.00004230318,0.00002544697,0.00003025677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002717797,0.0000142226,0.0002084407,0.00002588112,0.000007823905,0.0001687157,0.00004888496,0.0003454895,0.9981952,0.0001142374,0.0001586916,0.0006852653],"study_design_scores_gemma":[0.00001192846,0.00006434708,0.003850258,0.00001615044,0.0000188171,0.00048107,0.00005609012,0.003286619,0.9870352,0.0001390264,0.005033014,0.000007476585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650006,0.001030093,0.02150746,0.000332463,0.0002068896,0.0001549472,0.004645765,0.0004881682,0.006633685],"genre_scores_gemma":[0.967663,0.001122309,0.01705456,0.0002626773,0.00001919306,0.0001644145,0.005601244,0.0002688816,0.007843621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008930699,"threshold_uncertainty_score":0.002622366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02135438381891382,"score_gpt":0.2639349468106482,"score_spread":0.2425805629917344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}