{"id":"W4407029151","doi":"10.1016/j.neuron.2025.01.005","title":"Divergent sex-specific pannexin-1 mechanisms in microglia and T cells underlie neuropathic pain","year":2025,"lang":"en","type":"article","venue":"Neuron","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; Hotchkiss Brain Institute; McGill University Health Centre; University of Calgary","funders":"Canadian Institutes of Health Research; School of Medicine, New York University; Louise and Alan Edwards Foundation; Natural Sciences and Engineering Research Council of Canada; Hotchkiss Brain Institute","keywords":"Microglia; Neuroscience; Pannexin; Neuropathic pain; Psychology; Medicine; Biology; Inflammation; Gap junction; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003097116,0.0001305297,0.0001071709,0.000056179,0.00005244177,0.00002242828,0.0001131459,0.00009189584,0.00001474669],"category_scores_gemma":[0.0000279242,0.0001324467,0.00003605748,0.00008639887,0.00002817834,0.000002102541,0.0001329929,0.0001143638,0.000005144735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006957095,"about_ca_system_score_gemma":0.00002387286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001279619,"about_ca_topic_score_gemma":0.000004137647,"domain_scores_codex":[0.9989973,0.0002370548,0.0001523061,0.0003590235,0.00006330598,0.0001909717],"domain_scores_gemma":[0.9996767,0.00003473748,0.00002953093,0.0002021395,0.00001563127,0.0000412734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003206344,0.00003931456,0.0007766949,0.00002024835,0.00000598662,0.00002949628,0.00002397083,0.00007092092,0.9890668,0.000348947,0.0059467,0.003638817],"study_design_scores_gemma":[0.0006261683,0.0002784969,0.001994259,0.0000289342,0.00001113904,0.000007698655,0.00008258726,0.0003487415,0.9052184,0.0009181909,0.09024805,0.0002373244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738943,0.004661141,0.01970812,0.0004164826,0.0003820931,0.0001850612,0.000007582829,0.00001902622,0.0007261861],"genre_scores_gemma":[0.9957797,0.0008905754,0.0001658431,0.001429569,0.00006292326,0.000007457767,0.00001427847,0.00001499497,0.001634686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08430135,"threshold_uncertainty_score":0.5401019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00931446308340724,"score_gpt":0.2173016263751809,"score_spread":0.2079871632917736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}