{"id":"W4407032036","doi":"10.1128/jvi.01685-24","title":"mRNA vaccine-induced SARS-CoV-2 spike-specific IFN-γ and IL-2 T-cell responses are predictive of serological neutralization and are transiently enhanced by pre-existing cross-reactive immunity","year":2025,"lang":"en","type":"article","venue":"Journal of Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; St. Michael's Hospital; Lunenfeld-Tanenbaum Research Institute; York University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto; National Research Council Canada; Canada Foundation for Innovation; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Government of Ontario; University of Ottawa","keywords":"Biology; Virology; Neutralization; Serology; Immunity; Spike Protein; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Immunology; Antibody; Immune system; Virus; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513987,0.0002210161,0.0001833573,0.00006049965,0.00005056321,0.0002252674,0.0001030672,0.0001493424,0.0008667297],"category_scores_gemma":[0.0002987401,0.0001090198,0.0002904786,0.00004641231,0.0001002824,0.0001440842,0.0001215257,0.0002180328,0.0001615047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003596401,"about_ca_system_score_gemma":0.0002159657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00091873,"about_ca_topic_score_gemma":0.0006981333,"domain_scores_codex":[0.9999412,0.000009813446,0.00000261289,0.00001453151,0.00001317268,0.00001859862],"domain_scores_gemma":[0.9999309,0.00002326455,0.00002477122,0.000006932585,0.000008620619,0.000005577734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005822258,0.0001628303,0.02732891,0.00009483975,0.00005172064,0.000123877,0.00006389924,0.1463111,0.8151743,0.0008890752,0.0001463202,0.00907098],"study_design_scores_gemma":[0.00004364636,0.001622012,0.04695755,0.0000139825,0.00006925554,0.0002038275,0.0001065175,0.7014239,0.2474253,0.001149131,0.0009670517,0.00001780155],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930466,0.00006908656,0.006322511,0.00001796789,0.000003498528,0.000007537567,0.00007843396,0.00003115684,0.0004231698],"genre_scores_gemma":[0.9989512,0.00003377344,0.0005970461,0.000005279937,5.875376e-7,0.000007689211,0.00008101665,0.000002896883,0.0003204939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00091873,"threshold_uncertainty_score":0.002899528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05011719501023266,"score_gpt":0.3767324044415752,"score_spread":0.3266152094313425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}