{"id":"W4407033507","doi":"10.1038/s41389-025-00545-6","title":"Subtype-specific role for Jagged1 in promoting or inhibiting breast tumor formation","year":2025,"lang":"en","type":"article","venue":"Oncogenesis","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Cancer Society Research Institute; Mississippi IDeA Network of Biomedical Research Excellence; U.S. Department of Health and Human Services; National Institute of General Medical Sciences; U.S. Department of Defense","keywords":"Cancer research; Breast tumor; Cell biology; Biology; Chemistry; Medicine; Breast cancer; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003302661,0.0001245823,0.0001329726,0.00008326042,0.0001046586,0.00003379414,0.0001198823,0.00009155263,0.000016944],"category_scores_gemma":[0.00009149555,0.0001150291,0.00006870572,0.0001842235,0.00001880735,0.000008304685,0.00007030887,0.00004771836,0.00000709701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000357002,"about_ca_system_score_gemma":0.0001056761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001281183,"about_ca_topic_score_gemma":0.0001203277,"domain_scores_codex":[0.9991162,0.00004616263,0.0002554595,0.0002632765,0.00006709405,0.0002518146],"domain_scores_gemma":[0.999612,0.00002443744,0.00008591693,0.0001618534,0.00007898034,0.00003680111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002430476,0.00005809165,0.002195262,0.0001238956,0.00001096817,0.000002513144,0.0001118814,0.000009465621,0.9300265,0.0001404211,0.0003591715,0.06671879],"study_design_scores_gemma":[0.000740082,0.0001018388,0.001085656,0.0001096865,0.000008242348,0.00002937215,0.0002774013,0.0003388143,0.9677213,0.0001195166,0.02931273,0.0001553773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935861,0.0007081422,0.002113387,0.000202646,0.00008155435,0.0005434026,0.00005260204,0.00002169358,0.002690447],"genre_scores_gemma":[0.9970652,0.00004189328,0.001692516,0.0001896957,0.0001729609,0.0002046803,0.0001168778,0.00001866065,0.0004974863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06656341,"threshold_uncertainty_score":0.4690752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472417422302702,"score_gpt":0.255013775079091,"score_spread":0.240289600856064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}