{"id":"W4407064625","doi":"10.1016/j.ejca.2025.115277","title":"Response to letter to the editor on “Germline NGS targeted analysis in adult patients with sporadic adrenocortical carcinoma”","year":2025,"lang":"en","type":"letter","venue":"European Journal of Cancer","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Surgical Specialties (Canada)","funders":"","keywords":"Adrenocortical carcinoma; Germline; Medicine; Oncology; Internal medicine; Cancer research; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007787266,0.0003712422,0.0008433453,0.001233971,0.00005368165,0.00003375325,0.0004292403,0.0000993081,0.000352287],"category_scores_gemma":[0.0004056541,0.0002036182,0.0003269785,0.00150653,0.00005734465,0.00004001585,0.00006461085,0.002282988,0.00007884586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003021129,"about_ca_system_score_gemma":0.0003581992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004136416,"about_ca_topic_score_gemma":0.00003843343,"domain_scores_codex":[0.9964336,0.0007854036,0.0008666633,0.0003716559,0.001119018,0.0004236648],"domain_scores_gemma":[0.9979092,0.000200879,0.00042144,0.0004839318,0.000714058,0.0002704888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01145821,0.00007115854,0.01267645,0.00003009746,0.0005209785,0.01734626,0.0003635069,0.0005130699,0.00000512045,2.763263e-7,0.9560594,0.0009555166],"study_design_scores_gemma":[0.00181071,0.001271255,0.3667223,0.0007286478,0.0009211966,0.00003839974,0.00000911557,0.000005870388,0.00002453134,2.839429e-7,0.6282845,0.0001832159],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3737374,0.0001186556,0.0001065677,0.623758,0.00156053,0.0003764709,0.0000911331,0.000008889657,0.0002423071],"genre_scores_gemma":[0.2674174,0.000003992584,0.0001511914,0.7022907,0.02505771,0.000009344766,0.00004813212,0.00006332409,0.004958133],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3540459,"threshold_uncertainty_score":0.9918573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006635666349259249,"score_gpt":0.2434937693837805,"score_spread":0.2368581030345213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}