{"id":"W4407098309","doi":"10.1021/acs.orglett.4c04786","title":"Modular Assembly of Chalcones, <i>N-</i>Tosylhydrazones, and KSCN/KSeCN for the Synthesis of Trisubstituted Imidazo[2,1-<i>b</i>][1,3,4]thiadiazoles/selenadiazoles","year":2025,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Science North","funders":"Natural Science Basic Research Program of Shaanxi Province; Key Research and Development Projects of Shaanxi Province; National Natural Science Foundation of China","keywords":"Chemistry; Thiadiazoles; Modular design; Combinatorial chemistry; Organic chemistry; Programming language","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236222,0.000471673,0.0002425071,0.0002388,0.0001665706,0.0001887168,0.0003111001,0.0002302319,0.001057641],"category_scores_gemma":[0.0001056481,0.0002003398,0.000196268,0.0002497773,0.0002171153,0.0002514091,0.0002990935,0.0003843003,0.0005129816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003788274,"about_ca_system_score_gemma":0.0003817311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008231606,"about_ca_topic_score_gemma":0.002699158,"domain_scores_codex":[0.9998933,0.0000082167,0.00001202896,0.00003615341,0.00002372211,0.00002654694],"domain_scores_gemma":[0.9999378,0.000004562398,0.00001900412,0.00001089425,0.000009777316,0.00001801522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005051577,0.00002279162,0.0000767367,0.00005663668,0.00000578044,0.00007814214,0.00002743555,0.0003174321,0.9945301,0.0004118774,0.00008067517,0.004341812],"study_design_scores_gemma":[0.00001518658,0.0001729551,0.0004059574,0.000003284046,0.000007645319,0.00006442393,0.0000103236,0.0005866361,0.9961042,0.00004161664,0.002580245,0.000007586011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517187,0.001442327,0.03842963,0.0001124321,0.00009170674,0.0003314745,0.0005045529,0.0008073839,0.006561869],"genre_scores_gemma":[0.9634084,0.001110988,0.02887363,0.00005670973,0.00001333517,0.0001990865,0.0004663768,0.00006227419,0.005809159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001057641,"threshold_uncertainty_score":0.003538191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042880261169236,"score_gpt":0.2108808863906759,"score_spread":0.2004520837789836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}