{"id":"W4407100088","doi":"10.1016/j.mce.2025.112487","title":"p75NTR antagonist THX-B increases mature nerve growth factor secretion by bladder cells through decreased activity of matrix metalloproteinase-9","year":2025,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Urological Association","keywords":"Antagonist; Nerve growth factor; Secretion; Chemistry; Matrix metalloproteinase; Matrix (chemical analysis); Matrix metalloproteinase inhibitor; Matrix metalloproteinase 9; Cell biology; Pharmacology; Endocrinology; Internal medicine; Biology; Medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001917722,0.0002913603,0.0004777236,0.0001723486,0.0002539554,0.0004138779,0.0002200304,0.0002487686,0.002233376],"category_scores_gemma":[0.0002125999,0.0001730794,0.000319654,0.0001508091,0.0003113865,0.0003758511,0.0001918364,0.001013054,0.0003622841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00027615,"about_ca_system_score_gemma":0.000583345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009986112,"about_ca_topic_score_gemma":0.001295542,"domain_scores_codex":[0.999788,0.00002814378,0.0000204824,0.00002536693,0.00004607055,0.0000918673],"domain_scores_gemma":[0.999885,0.00002171206,0.00002004753,0.00001172337,0.00001007042,0.0000515689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001479959,0.0001559721,0.0002352761,0.00007012751,0.00001030766,0.0000878064,0.00002460834,0.0000621456,0.9950596,0.00007000036,0.0001129526,0.002631325],"study_design_scores_gemma":[0.0001218721,0.00231319,0.007574763,0.00001096704,0.00003809487,0.0002292298,0.000119598,0.0008863065,0.9867499,0.00004144769,0.001906626,0.000007971111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994743,0.002222985,0.001088472,0.0001752994,0.0001108947,0.00002713478,0.0002069204,0.00005560537,0.001369762],"genre_scores_gemma":[0.9941765,0.001280621,0.001393047,0.00007397066,0.00004262866,0.00003628327,0.0003281225,0.00000911287,0.002659547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002233376,"threshold_uncertainty_score":0.007471442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006532823673968632,"score_gpt":0.2514248497665183,"score_spread":0.2448920260925497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}