{"id":"W4407101507","doi":"10.1038/s41467-025-56452-2","title":"Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP(1,2) in a position elevated from the virion membrane","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; Argonne National Laboratory; National Institute of General Medical Sciences; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; National Institute of Allergy and Infectious Diseases; Medical Research Council; U.S. Department of Health and Human Services; Basic Energy Sciences; Institute of Medical Science, University of Tokyo; University of Toronto; University of California, San Diego; Office of Science; Defense Advanced Research Projects Agency; Eli Lilly and Company; U.S. Department of Defense; U.S. Department of Energy; European Commission; Max-Planck-Gesellschaft; Frederick National Laboratory for Cancer Research; National Cancer Institute; Emory University; National Center for Global Health and Medicine; Chinese Academy of Sciences; Battelle; National Institutes of Health","keywords":"Ebola virus; Epitope; Monoclonal antibody; Viremia; Virology; Ebolavirus; Neutralization; Glycoprotein; Antibody; Virus; Biology; Medicine; Immunology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001403027,0.0003080028,0.0002039132,0.0001505295,0.0001422155,0.000214703,0.0002715577,0.0004003074,0.001115709],"category_scores_gemma":[0.0000943886,0.00008809828,0.0002194255,0.00005334915,0.0002032083,0.0001585033,0.0001262277,0.0006637055,0.0003962961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001509127,"about_ca_system_score_gemma":0.0001230664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003443139,"about_ca_topic_score_gemma":0.0003686478,"domain_scores_codex":[0.9999226,0.00001778219,0.00000421718,0.0000136032,0.00001500551,0.0000267974],"domain_scores_gemma":[0.99994,0.00001253774,0.00001413041,0.000007593916,0.000007913535,0.00001775964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002022322,0.00008326753,0.0002266191,0.00002589683,0.0000095097,0.00003409363,0.000007337217,0.000100031,0.9977175,0.0001167717,0.0001292781,0.001347467],"study_design_scores_gemma":[0.0000477071,0.00159967,0.005283175,0.00001310718,0.00002277771,0.0003893972,0.00001673042,0.001355588,0.9882305,0.000155815,0.002880143,0.000005535162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919333,0.001914328,0.003214156,0.0002664821,0.00007679098,0.00003061183,0.000347936,0.0001556649,0.00206084],"genre_scores_gemma":[0.9947439,0.0008372845,0.00203622,0.0001411438,0.00002693615,0.00002101259,0.0003820613,0.00001468688,0.001796756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115709,"threshold_uncertainty_score":0.003732443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025103587979777,"score_gpt":0.363356300039836,"score_spread":0.3331052641600382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}