{"id":"W4407107618","doi":"10.1007/s00401-025-02849-8","title":"IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread","year":2025,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; Leibniz-Gemeinschaft; Roman, Marga und Mareille Sobek Stiftung; Universitätsklinikum Heidelberg; Fritz Thyssen Stiftung; Albert-Ludwigs-Universität Freiburg; Bundesministerium für Bildung und Forschung; Novo Nordisk; Gottfried Wilhelm Leibniz Universität Hannover; Deutsche Forschungsgemeinschaft","keywords":"Mutant; Methylation; Biology; Component (thermodynamics); Astrocytoma; Pathology; Medicine; Cancer research; Genetics; Glioma; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008950182,0.0002935046,0.0003556542,0.0004799185,0.0002691651,0.0002785311,0.000129717,0.0002247536,0.00141249],"category_scores_gemma":[0.0004215275,0.0001145555,0.0001912585,0.0003452341,0.000188876,0.0001411946,0.0001958815,0.0002055271,0.0002828565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001747747,"about_ca_system_score_gemma":0.0001822208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001387589,"about_ca_topic_score_gemma":0.002024747,"domain_scores_codex":[0.9999042,0.00001048638,0.00001253234,0.00002379687,0.00002477123,0.00002429424],"domain_scores_gemma":[0.9996741,0.00003595715,0.0001228087,0.00003950257,0.00003620959,0.00009133255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006535532,0.00003533174,0.9274508,0.00004901521,0.00008748261,0.006108631,0.0001477522,0.0002326285,0.05298445,0.0001276291,0.0001299003,0.01199293],"study_design_scores_gemma":[0.000009810543,0.0001577533,0.9729591,0.000005202231,0.00004555889,0.02200033,0.0001316035,0.0004398276,0.003623258,0.0001958247,0.0004234355,0.000008253816],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991421,0.0001636483,0.0002299246,0.000008705204,0.000001697016,0.000006014361,0.00007051286,0.00001073919,0.0003666987],"genre_scores_gemma":[0.9994465,0.00006209456,0.000159829,0.000004473845,0.000002513305,0.000002049081,0.0001187696,0.000002983314,0.0002009256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00141249,"threshold_uncertainty_score":0.004725218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01507960776829293,"score_gpt":0.2605413946371261,"score_spread":0.2454617868688331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}