{"id":"W4407115121","doi":"10.1002/glia.24677","title":"Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease","year":2025,"lang":"en","type":"article","venue":"Glia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institutes of Health","keywords":"Biology; Induced pluripotent stem cell; Microglia; Neuropathology; Astrocyte; Neuroinflammation; Disease; Neuroscience; Gene; Genetics; Inflammation; Central nervous system; Immunology; Pathology; Medicine; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008565412,0.00007396959,0.0001606457,0.0001573065,0.00002819621,0.000005676998,0.00003594143,0.00002589449,0.000009715246],"category_scores_gemma":[0.0001810455,0.00006781037,0.00002255577,0.0002412606,0.00003511628,0.00002114809,0.00005672733,0.00004259849,0.000003432021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001911096,"about_ca_system_score_gemma":0.0001340863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000223386,"about_ca_topic_score_gemma":0.00001553431,"domain_scores_codex":[0.999316,0.00005440872,0.0001563584,0.0001803552,0.0001458224,0.0001470345],"domain_scores_gemma":[0.9993719,0.00005799801,0.00003383037,0.0001643375,0.00009510003,0.0002768299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005644045,0.002411105,0.8871856,0.0003979823,0.003280651,0.000412401,0.000842766,0.0008287678,0.08880114,0.004309614,0.0003863698,0.005499599],"study_design_scores_gemma":[0.001339898,0.0002478061,0.9191778,0.0001061389,0.0006014902,5.342802e-7,0.00003221954,0.0003446018,0.07584246,0.002253496,0.000005404228,0.00004820577],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876383,0.005095379,0.006066823,0.0002234916,0.00001122587,0.0005618103,0.0003607564,0.000005976692,0.00003625741],"genre_scores_gemma":[0.9975497,0.00008811962,0.00223745,0.00006338033,0.000002380307,0.00003498611,0.0000147621,0.000004072376,0.000005124754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03199219,"threshold_uncertainty_score":0.2765226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00657660547245322,"score_gpt":0.2800852487500524,"score_spread":0.2735086432775992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}