{"id":"W4407131759","doi":"10.1101/2025.02.03.636181","title":"Differential time-restricted sensitivity of enveloped viruses to Sec61 translocon blockade","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Sensitivity (control systems); Differential (mechanical device); Blockade; Translocon; Virology; Physics; Biology; Medicine; Internal medicine; Engineering; Genetics; Electronic engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001614807,0.0002587134,0.0002663943,0.000133914,0.00008188965,0.0003395461,0.0001559073,0.0002680889,0.001108598],"category_scores_gemma":[0.000303962,0.0001085537,0.0001926036,0.0001491316,0.000166281,0.0002040052,0.000168753,0.0004601322,0.0003005888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002080401,"about_ca_system_score_gemma":0.0001168609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002966486,"about_ca_topic_score_gemma":0.0003142621,"domain_scores_codex":[0.9998117,0.00004166622,0.00002583946,0.00003168037,0.00004318856,0.00004593296],"domain_scores_gemma":[0.9997384,0.00009464745,0.00005207797,0.00004232015,0.00003422458,0.00003831341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001948408,0.00003183107,0.00008500094,0.00001632667,0.000003376227,0.00001714555,0.000009879931,0.00006136037,0.9991025,0.00003233147,0.00001151135,0.0004340062],"study_design_scores_gemma":[0.00001025249,0.0006120435,0.001369746,0.000002790538,0.000006084014,0.00005205365,0.00001082195,0.0004086268,0.9970251,0.00001205208,0.0004876118,0.00000291113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996738,0.001312895,0.0009107993,0.00003120779,0.00003465442,0.00002396246,0.0002259465,0.00003173061,0.0006907544],"genre_scores_gemma":[0.9970152,0.0005334098,0.0006924756,0.00002896318,0.00001114987,0.00003181823,0.0004227066,0.00001317345,0.001251039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108598,"threshold_uncertainty_score":0.003708601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123501838793538,"score_gpt":0.2738261442118156,"score_spread":0.2525911258238802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}