{"id":"W4407133975","doi":"10.1016/j.isci.2025.111946","title":"Alterations in ether phospholipids metabolism activate the conserved UPR-Xbp1- PDIA3/ERp60 signaling to maintain intestinal homeostasis","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Izaak Walton Killam Health Centre; Dalhousie University","funders":"National Center for Research Resources; Natural Sciences and Engineering Research Council of Canada; Research Nova Scotia; Canadian Institutes of Health Research; Dalhousie University","keywords":"Cell biology; Homeostasis; XBP1; Signal transduction; Chemistry; Metabolism; Biology; Biochemistry; Gene; RNA splicing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002944,0.0002694717,0.0001477474,0.0002198777,0.0001396503,0.0002441739,0.0001103861,0.0001968518,0.001259257],"category_scores_gemma":[0.00006860639,0.00009426447,0.0002845451,0.0001258472,0.0001195217,0.0002944542,0.0002953677,0.0004474726,0.0003319159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427878,"about_ca_system_score_gemma":0.0001258326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002280496,"about_ca_topic_score_gemma":0.0002999942,"domain_scores_codex":[0.9999244,0.000008178031,0.000006533514,0.00001737482,0.00002091233,0.00002255416],"domain_scores_gemma":[0.9999523,0.000003039674,0.00001778299,0.000004866994,0.000008298195,0.00001366324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006826749,0.000007503592,0.0007078074,0.00002785154,0.000005163152,0.0001508279,0.000007527574,0.00003084354,0.996919,0.0001516984,0.00005581493,0.001867744],"study_design_scores_gemma":[0.00001972719,0.000180585,0.05495263,0.00001470276,0.0000389027,0.001038112,0.0001051251,0.001354964,0.9349681,0.0003548149,0.006962141,0.00001020319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843829,0.003823548,0.007475414,0.0003116849,0.00005652608,0.00004087621,0.0008205702,0.0001516975,0.00293679],"genre_scores_gemma":[0.9927853,0.001503276,0.002030996,0.00009906221,0.000009473,0.00001684945,0.0006040207,0.00001472815,0.002936252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259257,"threshold_uncertainty_score":0.004212677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045626777798674,"score_gpt":0.2783190021640241,"score_spread":0.2678627343860373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}