{"id":"W4407136687","doi":"10.1080/21645515.2025.2460749","title":"PfCSP-ferritin nanoparticle malaria vaccine antigen formulated with aluminum-salt and CpG 1018® adjuvants: Preformulation characterization, antigen-adjuvant interactions, and mouse immunogenicity studies","year":2025,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Creative Commons; Deutsches Krebsforschungszentrum; Bill and Melinda Gates Foundation","keywords":"Adjuvant; Immunogenicity; Antigen; Malaria vaccine; Malaria; Virology; Ferritin; Immunology; Medicine; Biology; Plasmodium falciparum; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002216487,0.0002929354,0.0001084257,0.0001207954,0.00005404957,0.00007750595,0.0001052085,0.0001878112,0.0003161972],"category_scores_gemma":[0.0001169141,0.00009104126,0.0001374633,0.00008189324,0.00009606384,0.000105225,0.00007709852,0.0002057338,0.0001273103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001334607,"about_ca_system_score_gemma":0.00008291754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004856912,"about_ca_topic_score_gemma":0.0005682547,"domain_scores_codex":[0.9999316,0.000009466604,0.00000463652,0.00001494607,0.00002550955,0.00001389265],"domain_scores_gemma":[0.999953,0.000007362239,0.00001498041,0.000003022229,0.00001298154,0.000008598535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003567466,0.00002042778,0.0000875093,0.00001688304,0.00000121972,0.000009649492,0.000007451354,0.00008048568,0.9992429,0.00001632629,0.000007046536,0.0004745395],"study_design_scores_gemma":[0.000007511155,0.0007448518,0.001365793,0.00000369341,0.000008958094,0.00007124033,0.000007171289,0.001030175,0.9961456,0.00001272424,0.0005994231,0.000002851554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962696,0.00040811,0.002762345,0.00001734297,0.000007718256,0.00003514651,0.00008286376,0.00002003793,0.0003968425],"genre_scores_gemma":[0.9935896,0.0003774538,0.004546878,0.00002155458,0.000005461356,0.0000376817,0.0002465232,0.000009475631,0.001165348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004856912,"threshold_uncertainty_score":0.001172245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582417610719239,"score_gpt":0.2921995313375504,"score_spread":0.2763753552303581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}