{"id":"W4407141736","doi":"10.1093/pnasnexus/pgaf020","title":"Selective inhibitors of the TrkC.T1 receptor reduce retinal inflammation and delay neuronal death in a model of retinitis pigmentosa","year":2025,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Retinitis pigmentosa; Retinal; Medicine; Inflammation; Retinal Disorder; Neuroscience; Ophthalmology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002033159,0.0006683542,0.0005334818,0.0005227579,0.0002503056,0.0003017796,0.0004258809,0.0005424563,0.001604362],"category_scores_gemma":[0.0001464152,0.0002051684,0.0003132441,0.0002135957,0.0003668425,0.000314127,0.0001179063,0.001180921,0.0003377277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005099254,"about_ca_system_score_gemma":0.0004433144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001696816,"about_ca_topic_score_gemma":0.002730189,"domain_scores_codex":[0.9998079,0.00002814174,0.00001694815,0.00003191612,0.00004790455,0.00006719405],"domain_scores_gemma":[0.9997882,0.0000318599,0.00006257027,0.00002385546,0.00002212312,0.00007130623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001067999,0.0004821385,0.00007732637,0.00006397535,0.00001711301,0.00006268885,0.00001777465,0.0001793031,0.9956126,0.000156629,0.0001441194,0.002118167],"study_design_scores_gemma":[0.000158499,0.003553872,0.0008312045,0.00001069711,0.00003108878,0.0001426814,0.00003244523,0.001212821,0.9928508,0.00006367412,0.001104314,0.000007924588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992137,0.002623833,0.002177184,0.0003243862,0.0001380847,0.0000795239,0.0003298329,0.0002375307,0.001952637],"genre_scores_gemma":[0.9889984,0.002087076,0.002557263,0.0001120836,0.00002922506,0.0001082939,0.0002530201,0.00003423275,0.005820378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696816,"threshold_uncertainty_score":0.0053671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008603797849803389,"score_gpt":0.2354504933051329,"score_spread":0.2268466954553295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}