{"id":"W4407141999","doi":"10.3390/genes16020195","title":"Maternal and Parent-of-Origin Gene–Environment Effects on the Etiology of Orofacial Clefting","year":2025,"lang":"en","type":"article","venue":"Genes","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Single-nucleotide polymorphism; Genetics; Gene–environment interaction; Gene; Genotype; Genome-wide association study; Candidate gene; Biology; Genetic association; Folic acid; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373247,0.00006101084,0.0000869776,0.00002139734,0.00003731538,0.000003816672,0.00008933848,0.00006186033,0.00001495728],"category_scores_gemma":[0.00002237392,0.00004231198,0.0000329401,0.00002316468,0.00007935482,4.880751e-7,0.00009680202,0.00003643579,0.000002156478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003145957,"about_ca_system_score_gemma":0.00001853481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002489151,"about_ca_topic_score_gemma":0.000004035069,"domain_scores_codex":[0.9995233,0.00007252821,0.0001035987,0.0001306391,0.00006097401,0.0001089889],"domain_scores_gemma":[0.9997459,0.00004301695,0.0000346074,0.000147115,0.00001207984,0.00001725938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004811501,0.000009628175,0.2618366,0.00003892006,0.00003614323,5.910314e-7,0.00001234163,0.00002199937,0.716099,0.0002009096,0.00007586586,0.02161991],"study_design_scores_gemma":[0.0001856059,0.000121517,0.1713772,0.00001600812,0.000008278255,0.000001344715,0.00001189278,0.00001930006,0.8203816,0.00007663207,0.007762051,0.00003845894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985216,0.0005512759,0.0001050057,0.0001575611,0.00008604082,0.0001033538,0.000007898235,0.000001400382,0.0004659003],"genre_scores_gemma":[0.9984068,0.001181056,0.00007119169,0.0000600064,0.0000702029,0.000009159245,0.00000743912,0.000003847194,0.0001902765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1042827,"threshold_uncertainty_score":0.1725432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01504867538154535,"score_gpt":0.282990269013533,"score_spread":0.2679415936319876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}