{"id":"W4407146827","doi":"10.1007/978-3-642-27843-3_43-3","title":"Thrombotic Thrombocytopenic Purpura, Atypical Hemolytic Uremic Syndrome, and Spectrum of Thrombotic Microangiopathy","year":2025,"lang":"en","type":"book-chapter","venue":"Pediatric Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Hospital for Sick Children","funders":"","keywords":"Thrombotic microangiopathy; Medicine; Thrombotic thrombocytopenic purpura; Atypical hemolytic uremic syndrome; Schistocyte; Internal medicine; Nephrology; Hemolytic anemia; Cardiology; Platelet; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003365516,0.0009755326,0.00255654,0.0009075264,0.0002120886,0.00002302315,0.0009093368,0.00139591,0.005617073],"category_scores_gemma":[0.000107895,0.0009754708,0.000551174,0.0001916906,0.0008933077,0.0000872887,0.0009289728,0.001019595,0.0009500169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001833692,"about_ca_system_score_gemma":0.0005273827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006464517,"about_ca_topic_score_gemma":0.00006060859,"domain_scores_codex":[0.9957845,0.0002569131,0.001527774,0.001309909,0.0001518381,0.0009690177],"domain_scores_gemma":[0.996699,0.0009475513,0.0009132944,0.001216852,0.0001219952,0.0001012559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.003420546,0.002069057,0.06177383,0.01154148,0.01535213,0.001788854,0.0008094732,0.00003357901,0.03229048,0.3669187,0.501052,0.002949969],"study_design_scores_gemma":[0.02981132,0.01236144,0.3702548,0.002785997,0.05195844,0.02236968,0.0002945348,0.00005243851,0.00276936,0.2215538,0.2734505,0.01233761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6764104,0.2365843,0.0002487378,0.002082242,0.007605125,0.006793569,0.001872559,0.0007120078,0.06769107],"genre_scores_gemma":[0.9144855,0.003838745,0.0001184972,0.0005794979,0.0003094683,0.00006572088,0.0005767857,0.0001408082,0.07988495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.308481,"threshold_uncertainty_score":0.9999005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031044319464137,"score_gpt":0.220032386934911,"score_spread":0.2097219437402696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}