{"id":"W4407148244","doi":"10.1002/jcsm.13701","title":"Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy","year":2025,"lang":"en","type":"article","venue":"Journal of Cachexia Sarcopenia and Muscle","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; Children's Hospital of Eastern Ontario; McMaster University Medical Centre; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Ministry of Economic Development, Job Creation and Trade; Ministero dello Sviluppo Economico; Canada Research Chairs; Muscular Dystrophy Canada","keywords":"Skeletal muscle; Spinal muscular atrophy; SMA*; Medicine; Mitochondrion; Autophagy; Mitochondrial biogenesis; Muscle atrophy; Myogenesis; Endocrinology; Internal medicine; Biology; Cell biology; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499069,0.0003603342,0.0004114151,0.0004253125,0.0001617943,0.0002711869,0.0001550085,0.0004330922,0.002068144],"category_scores_gemma":[0.0001015562,0.0001742741,0.0002691415,0.0001802147,0.0003102222,0.000191476,0.0002482843,0.0004191046,0.0003322965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881926,"about_ca_system_score_gemma":0.0001300705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003790063,"about_ca_topic_score_gemma":0.0008485747,"domain_scores_codex":[0.9998667,0.00002213473,0.00001355297,0.00004436323,0.00002779613,0.00002544841],"domain_scores_gemma":[0.9998746,0.00000794937,0.00006370918,0.000007801505,0.00001322018,0.00003281037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006830152,0.00003479788,0.001958831,0.0000962776,0.00001818719,0.0001792855,0.00001950267,0.00003218656,0.9953929,0.00003928335,0.00007032356,0.001475474],"study_design_scores_gemma":[0.0001372389,0.002591002,0.4623126,0.0001197765,0.0001748955,0.002326266,0.0003373449,0.0008390229,0.5249053,0.0002689528,0.005965776,0.00002192481],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929712,0.004828498,0.0007119383,0.0000756566,0.00003904722,0.00002789634,0.0005215805,0.00006537756,0.0007587779],"genre_scores_gemma":[0.9951018,0.001801864,0.0005545478,0.00005652663,0.00001533864,0.00006334964,0.0005462573,0.00001505278,0.001845223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002068144,"threshold_uncertainty_score":0.006918609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181450976154969,"score_gpt":0.2894588733568106,"score_spread":0.2776443635952609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}