{"id":"W4407152395","doi":"10.1186/s13148-025-01821-3","title":"Age-related changes in DNA methylation in a sample of elderly Brazilians","year":2025,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; Hatch (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; Conselho Nacional de Desenvolvimento Científico e Tecnológico; McLaughlin Centre, University of Toronto; University of Toronto; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"dNaM; Differentially methylated regions; DNA methylation; CpG site; Biology; Methylation; Genetics; Genome-wide association study; Epigenetics; Gene; Genotype; Gene expression; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005463114,0.0002570979,0.0004029665,0.000811003,0.0004525824,0.000296251,0.0002865086,0.0002886463,0.0008570334],"category_scores_gemma":[0.001972679,0.0002353972,0.0003277023,0.0007512372,0.0002663405,0.0001294721,0.0004558929,0.0001597644,0.0001407496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003745706,"about_ca_system_score_gemma":0.0003026749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05487407,"about_ca_topic_score_gemma":0.06134107,"domain_scores_codex":[0.9997932,0.00004348782,0.00001829294,0.00006736559,0.00004101745,0.00003667707],"domain_scores_gemma":[0.9996076,0.00005660891,0.0001320028,0.00005139966,0.0001044673,0.00004782859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001162593,0.00001675259,0.9896031,0.00005012228,0.0000731105,0.000149839,0.001377031,0.00002248722,0.003209474,0.00004484456,0.0001110648,0.005225981],"study_design_scores_gemma":[0.000003933335,0.00004865828,0.9986308,0.00001384983,0.00003764042,0.0002331056,0.0004088119,0.0000421823,0.000107355,0.00002959456,0.0004415084,0.000002486308],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986352,0.0004201775,0.0001569064,0.00003848015,0.00000286691,0.000012846,0.0004029376,0.000003250897,0.0003272001],"genre_scores_gemma":[0.9988506,0.0003621,0.0002121919,0.00003888487,0.000004054969,0.00001886231,0.0003422373,0.000002513513,0.0001685587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05487407,"threshold_uncertainty_score":0.1091093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02888882601080107,"score_gpt":0.3632115370011105,"score_spread":0.3343227109903095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}