{"id":"W4407152395","doi":"10.1186/s13148-025-01821-3","title":"Age-related changes in DNA methylation in a sample of elderly Brazilians","year":2025,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; Hatch (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; Conselho Nacional de Desenvolvimento Científico e Tecnológico; McLaughlin Centre, University of Toronto; University of Toronto; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"dNaM; Differentially methylated regions; DNA methylation; CpG site; Biology; Methylation; Genetics; Genome-wide association study; Epigenetics; Gene; Genotype; Gene expression; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001078405,0.0001470973,0.000339909,0.000180107,0.00002165257,0.00001008188,0.0001996031,0.0004454076,0.00001757671],"category_scores_gemma":[0.001535976,0.0001573913,0.0001108021,0.0004258869,0.0001583725,0.000002054932,0.0001002105,0.0001888272,0.000002390084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001698202,"about_ca_system_score_gemma":0.00011712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001134072,"about_ca_topic_score_gemma":0.00357453,"domain_scores_codex":[0.9980258,0.0002893447,0.0009288894,0.0004036106,0.0001163833,0.0002359663],"domain_scores_gemma":[0.9989569,0.0003149445,0.0001790429,0.0004061685,0.00008716822,0.00005583162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001550453,0.0005734523,0.5003719,0.00008233108,0.00007273386,0.000006737209,0.0001480644,0.00281194,0.306051,0.0007691213,0.00007119321,0.1888865],"study_design_scores_gemma":[0.002302883,0.001071831,0.6363045,0.0001175151,0.00003893159,1.873442e-7,0.00007127481,0.001102829,0.326607,0.02005485,0.01200638,0.000321737],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902286,0.002591274,0.005033039,0.000361457,0.0003198238,0.0002882117,0.00001795273,0.000006902615,0.001152766],"genre_scores_gemma":[0.9938788,0.003254309,0.002283233,0.0001167529,0.00005349473,0.00001584308,0.00009986811,0.00001617845,0.0002815674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1885648,"threshold_uncertainty_score":0.6418233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02888882601080107,"score_gpt":0.3632115370011105,"score_spread":0.3343227109903095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}