{"id":"W4407165295","doi":"10.1101/2025.01.31.635709","title":"Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancers","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Center for Individualized Medicine, Mayo Clinic; Fondation pour la Recherche Médicale; National Cancer Institute; National Science Foundation; National Institutes of Health; Glenn Foundation for Medical Research","keywords":"Vulnerability (computing); Fidelity; Heterochromatin; Lymphoma; Cancer research; Medicine; Computer science; Biology; Internal medicine; Telecommunications; Genetics; Chromatin; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002646456,0.0001788387,0.0002256058,0.0002876664,0.0001136902,0.0003153497,0.0001834678,0.0001734197,0.002398072],"category_scores_gemma":[0.0001848096,0.00009039677,0.000135922,0.000187516,0.0001713716,0.0001243136,0.0002279453,0.0003725702,0.0003578617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003670967,"about_ca_system_score_gemma":0.0001605982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005364356,"about_ca_topic_score_gemma":0.001030873,"domain_scores_codex":[0.9998446,0.00003100231,0.00001036167,0.00002628115,0.00005546343,0.00003233229],"domain_scores_gemma":[0.9998945,0.00001925676,0.00003235013,0.00001889777,0.0000179306,0.00001719072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001764651,0.00004977341,0.002247282,0.0001183902,0.00002326321,0.00008251694,0.00001675232,0.0002191679,0.9796469,0.0003611726,0.0002939219,0.01676444],"study_design_scores_gemma":[0.00004496174,0.001411459,0.03099269,0.00002783274,0.00008030868,0.002009925,0.00007995959,0.001428383,0.9441629,0.0003726487,0.01937958,0.00000929934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649294,0.01618878,0.005501615,0.0005390198,0.00003072562,0.00009061473,0.0006624466,0.0003472237,0.01171021],"genre_scores_gemma":[0.9956065,0.001549432,0.0005389104,0.00007469572,0.000005753415,0.00001758607,0.0002872403,0.000009718648,0.001910212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002398072,"threshold_uncertainty_score":0.008022368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174199521123156,"score_gpt":0.2474424407596922,"score_spread":0.2357004455484606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}