{"id":"W4407166461","doi":"10.21203/rs.3.rs-5049190/v1","title":"Self-Assembled DNA Nanocarriers for Treating Bone Fracture and Surgery-related MRSA Infection","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Institute of Musculoskeletal Health and Arthritis; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Nanocarriers; Medicine; Methicillin-resistant Staphylococcus aureus; Staphylococcus aureus; Biology; Pharmacology; Drug; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000146736,0.0002247954,0.000259222,0.0002306817,0.0001291903,0.0002341613,0.0002480307,0.000501115,0.001164782],"category_scores_gemma":[0.000221112,0.0001487847,0.0002709678,0.0001245805,0.0001379729,0.0001904373,0.0003066971,0.0003827742,0.0003196574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003415458,"about_ca_system_score_gemma":0.0002890278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001230167,"about_ca_topic_score_gemma":0.001783407,"domain_scores_codex":[0.9999002,0.00001081727,0.000005409596,0.0000252316,0.00003398004,0.00002442009],"domain_scores_gemma":[0.9999357,0.00001682487,0.00001313092,0.000004003871,0.00001560723,0.00001466182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001456827,0.00004486457,0.00006155438,0.000128718,0.00001225259,0.00005668817,0.00002903154,0.0007439995,0.9896018,0.0001597711,0.0001811026,0.008834573],"study_design_scores_gemma":[0.00004027636,0.000372002,0.0004279837,0.00001192847,0.00003788127,0.00009130809,0.00001664607,0.004651673,0.9905477,0.00008124657,0.003711167,0.00001018146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9384962,0.01637308,0.03920562,0.000636267,0.0004178533,0.0001541359,0.0002380702,0.0003813424,0.004097277],"genre_scores_gemma":[0.969518,0.002685663,0.02052893,0.0002614916,0.00005219065,0.00009111843,0.000128547,0.00004267296,0.006691325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001230167,"threshold_uncertainty_score":0.003896654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0185670993934429,"score_gpt":0.3637154368272777,"score_spread":0.3451483374338348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}