{"id":"W4407167663","doi":"10.1021/acs.biochem.4c00811","title":"The Huntingtin Transport Complex","year":2025,"lang":"en","type":"review","venue":"Biochemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Huntingtin; Chemistry; Biophysics; Computational biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590311,0.0009386655,0.000657664,0.001292794,0.0002798041,0.00129283,0.0006720101,0.0008238715,0.003689553],"category_scores_gemma":[0.0001679391,0.0001903779,0.0002422148,0.0009909426,0.0004072535,0.0006449831,0.0007299884,0.00095483,0.004680963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001188801,"about_ca_system_score_gemma":0.001037738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002004966,"about_ca_topic_score_gemma":0.00217456,"domain_scores_codex":[0.999909,0.000007779915,0.000009942943,0.00002044713,0.00003847367,0.00001433917],"domain_scores_gemma":[0.9999378,0.000009203159,0.00001443459,0.000002810582,0.00001971831,0.00001611057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009183431,0.00004906072,0.0003142745,0.004621017,0.0001032728,0.000381008,0.00005291722,0.0003745958,0.0141747,0.008924959,0.0661737,0.9047388],"study_design_scores_gemma":[0.00001059299,0.00002925556,0.0005126655,0.000491642,0.00003340144,0.0009110834,0.00001320807,0.00007707446,0.002301186,0.001244929,0.9943663,0.000008635211],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007813303,0.9875464,0.0007655059,0.0003683059,0.0004586701,0.00002860132,0.000203855,0.00009408496,0.00975323],"genre_scores_gemma":[0.007103798,0.9749957,0.0007702805,0.0005581519,0.0003241025,0.00004162953,0.0009014156,0.00001173936,0.01529316],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003689553,"threshold_uncertainty_score":0.01234281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07319103834065846,"score_gpt":0.3440091801049691,"score_spread":0.2708181417643106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}