{"id":"W4407172390","doi":"10.1186/s13293-025-00694-8","title":"Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats","year":2025,"lang":"en","type":"article","venue":"Biology of Sex Differences","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; University of Toronto; University of British Columbia; Centre for Addiction and Mental Health","funders":"University of British Columbia; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Canadian Institutes of Health Research; Cure Alzheimer's Fund; Alzheimer's Association","keywords":"Neurogenesis; Dentate gyrus; Hippocampal formation; Microglia; Progenitor cell; Neural stem cell; Apolipoprotein E; Hippocampus; Endocrinology; Biology; Internal medicine; Neuroscience; Medicine; Stem cell; Inflammation; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001524222,0.0002516628,0.000518953,0.0002625468,0.00009324493,0.0000174823,0.0004104003,0.0001410287,0.00001989528],"category_scores_gemma":[0.00009671329,0.0002007221,0.0000635582,0.0004097593,0.0005277604,0.00004568948,0.0001302937,0.0001483073,0.000004834578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007543631,"about_ca_system_score_gemma":0.00005397016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001789904,"about_ca_topic_score_gemma":0.000007760812,"domain_scores_codex":[0.9978703,0.0004787088,0.0004970075,0.0006740696,0.0001687911,0.0003110735],"domain_scores_gemma":[0.9984716,0.0009785219,0.0002049775,0.0002545401,0.00002956346,0.00006080385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000139385,0.0001788,0.03748764,0.00007385691,0.000008692551,0.0000116081,0.0001440883,0.000004186041,0.9560269,0.001386933,0.000003988647,0.00453395],"study_design_scores_gemma":[0.0003338045,0.0005267294,0.05397867,0.00006208004,0.00001176448,0.000003026052,0.00009525585,0.00003471856,0.9442118,0.0005414313,0.00006524447,0.0001355236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986103,0.0003548189,0.00001544138,0.00004378756,0.0004874921,0.0003201523,0.00004711582,0.0000285681,0.00009228312],"genre_scores_gemma":[0.9988481,0.0008082145,0.00006427734,0.0001529042,0.00002215816,0.0000227918,9.504616e-7,0.00001093913,0.00006967514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01649102,"threshold_uncertainty_score":0.818521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05326761117046541,"score_gpt":0.2630102538068597,"score_spread":0.2097426426363942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}