{"id":"W4407177262","doi":"10.3390/cells14030223","title":"The Importance of Monitoring Antigen-Specific Memory B Cells, and How ImmunoSpot Assays Are Suitable for This Task","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"","keywords":"ELISPOT; Memory B cell; Antigen; Immunology; B cell; Antibody; Immune system; Antibody Repertoire; Biology; Humoral immunity; Immunogenicity; B-1 cell; Computational biology; T cell; Antigen-presenting cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007556256,0.0006707972,0.002108219,0.0001812951,0.0006564855,0.00007052637,0.0009707036,0.001210319,0.00009122443],"category_scores_gemma":[0.00006544204,0.0004744337,0.0006171903,0.0002743812,0.0005945942,0.00007682482,0.0003811447,0.0009355969,0.0001162512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008511225,"about_ca_system_score_gemma":0.0002543395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001720837,"about_ca_topic_score_gemma":0.000005913049,"domain_scores_codex":[0.9971373,0.0004138354,0.0007841386,0.0007681568,0.00005841961,0.0008381463],"domain_scores_gemma":[0.9956863,0.001944736,0.001059114,0.001103798,0.0001771387,0.00002892004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008754372,0.0001927064,0.00006385053,0.01101412,0.001483593,0.00001618576,0.0001654147,3.803043e-7,0.5372463,0.0002503409,0.08347273,0.3660068],"study_design_scores_gemma":[0.0004904669,0.00008239004,0.000004022477,0.002776518,0.000273051,0.00001936302,0.0002440343,6.926969e-8,0.1144303,0.0000288171,0.881265,0.0003860084],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003418511,0.9908497,0.00002874668,0.00005375479,0.005969727,0.001371783,0.0003892739,0.00005918719,0.0009359408],"genre_scores_gemma":[0.0004436784,0.9377145,0.00007252653,0.00001154317,0.0001246686,0.0001697149,0.0001554459,0.00006235865,0.06124552],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7977923,"threshold_uncertainty_score":0.9997708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257134921337038,"score_gpt":0.2580772711785877,"score_spread":0.2323637790448839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}