{"id":"W4407177262","doi":"10.3390/cells14030223","title":"The Importance of Monitoring Antigen-Specific Memory B Cells, and How ImmunoSpot Assays Are Suitable for This Task","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"","keywords":"ELISPOT; Memory B cell; Antigen; Immunology; B cell; Antibody; Immune system; Antibody Repertoire; Biology; Humoral immunity; Immunogenicity; B-1 cell; Computational biology; T cell; Antigen-presenting cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00249505,0.001402908,0.002036331,0.002507837,0.0002660326,0.001961081,0.001454828,0.002681482,0.001651095],"category_scores_gemma":[0.001901469,0.0005696258,0.0006525733,0.001537263,0.001659142,0.003706908,0.0009296684,0.004571555,0.002969509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001167592,"about_ca_system_score_gemma":0.001055118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039803,"about_ca_topic_score_gemma":0.0007806275,"domain_scores_codex":[0.9991683,0.0001916271,0.00006340235,0.0001866936,0.0003322354,0.00005780932],"domain_scores_gemma":[0.998782,0.0006576331,0.000128968,0.00005925967,0.0002895417,0.0000826569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007326079,0.00006465452,0.0002999756,0.01014279,0.00007823137,0.0001964798,0.0000796771,0.0008685303,0.00976,0.02018275,0.02497046,0.9332832],"study_design_scores_gemma":[0.00001175362,0.0001284259,0.0006218654,0.001729601,0.00005825758,0.001144535,0.00004996754,0.0002335897,0.002810336,0.006551642,0.9866187,0.00004134238],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001326584,0.9953789,0.001477287,0.0009817549,0.0005356942,0.000008844587,0.00002342573,0.00002416935,0.001437325],"genre_scores_gemma":[0.001458771,0.9937153,0.002022964,0.0009491256,0.0005676108,0.00002747135,0.00005245978,0.000009224436,0.001197023],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002681482,"threshold_uncertainty_score":0.01319522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257134921337038,"score_gpt":0.2580772711785877,"score_spread":0.2323637790448839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}