{"id":"W4407185614","doi":"10.1111/all.16490","title":"Epigenome‐Wide Association Study of Asthma Exacerbations in Europeans","year":2025,"lang":"en","type":"article","venue":"Allergy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Fundación Canaria Instituto de Investigación Sanitaria de Canarias; European Social Fund; Agencia Estatal de Investigación; Vetenskapsrådet; European Academy of Allergy and Clinical Immunology; Allergopharma; Bundesministerium für Bildung und Forschung; Sociedad Española de Neumología y Cirugía Torácica; Instituto de Salud Carlos III; ZonMw; European Respiratory Society; European Regional Development Fund; European Commission; Hjärt-Lungfonden; Lloyd's Tercentenary Research Foundation; Ministerio de Ciencia, Innovación y Universidades","keywords":"dNaM; Epigenetics; DNA methylation; Epigenome; Genome-wide association study; CpG site; Genetic association; Biology; Asthma; Methylation; Medicine; Bioinformatics; Genetics; Immunology; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002368518,0.0000650995,0.00009110388,0.00007716965,0.00002981203,0.000007338824,0.00009120278,0.00006308985,0.00001172145],"category_scores_gemma":[0.000236653,0.00007107123,0.00002936139,0.0001681502,0.000007252253,0.000001819099,0.00005688348,0.00004276622,0.000002628569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002617284,"about_ca_system_score_gemma":0.00003867939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001153069,"about_ca_topic_score_gemma":0.001578479,"domain_scores_codex":[0.9993046,0.0001129461,0.0002238076,0.000169736,0.00008355796,0.0001053425],"domain_scores_gemma":[0.9995918,0.00003981961,0.00008027612,0.0001905901,0.00008115244,0.00001640774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003814174,0.0007053368,0.8491246,0.00001007089,0.0001684931,0.000001629576,0.0004650117,0.003896238,0.1420925,0.0004910621,0.0006995235,0.002307387],"study_design_scores_gemma":[0.0008425341,0.0003005297,0.90948,0.000008145992,0.000006748986,1.046699e-8,0.0002681341,0.00004129495,0.02039774,0.0002315856,0.06832508,0.00009815984],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856083,0.0006145602,0.000779867,0.0001420033,0.00009785008,0.0001452835,0.000003077059,0.000004082131,0.012605],"genre_scores_gemma":[0.9967616,0.0002698707,0.0001046251,0.00006552503,0.00002720005,0.00001290005,0.00003816963,0.000007514913,0.002712546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1216947,"threshold_uncertainty_score":0.2898201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007218805349479216,"score_gpt":0.2539430297534279,"score_spread":0.2467242244039487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}