{"id":"W4407185614","doi":"10.1111/all.16490","title":"Epigenome‐Wide Association Study of Asthma Exacerbations in Europeans","year":2025,"lang":"en","type":"article","venue":"Allergy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Fundación Canaria Instituto de Investigación Sanitaria de Canarias; European Social Fund; Agencia Estatal de Investigación; Vetenskapsrådet; European Academy of Allergy and Clinical Immunology; Allergopharma; Bundesministerium für Bildung und Forschung; Sociedad Española de Neumología y Cirugía Torácica; Instituto de Salud Carlos III; ZonMw; European Respiratory Society; European Regional Development Fund; European Commission; Hjärt-Lungfonden; Lloyd's Tercentenary Research Foundation; Ministerio de Ciencia, Innovación y Universidades","keywords":"dNaM; Epigenetics; DNA methylation; Epigenome; Genome-wide association study; CpG site; Genetic association; Biology; Asthma; Methylation; Medicine; Bioinformatics; Genetics; Immunology; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00123934,0.0002529749,0.0005788653,0.0006860684,0.0003107711,0.0005337531,0.0003036897,0.0005377285,0.002219728],"category_scores_gemma":[0.00218553,0.000157763,0.001125041,0.001677532,0.0001620548,0.0002097983,0.0004892946,0.0003256273,0.0001600401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373473,"about_ca_system_score_gemma":0.0002344238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00761435,"about_ca_topic_score_gemma":0.005933755,"domain_scores_codex":[0.9989474,0.0003253197,0.0001015093,0.0004550913,0.00007918142,0.00009146125],"domain_scores_gemma":[0.9991198,0.0002504517,0.000263852,0.0001321353,0.0001199554,0.0001138402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006022807,0.00002236449,0.9899687,0.00009621457,0.001966215,0.0001839534,0.0000871641,0.0001482831,0.001526243,0.0001243618,0.0004760982,0.004798126],"study_design_scores_gemma":[0.00002266062,0.00003632273,0.9984519,0.00001564795,0.0003853435,0.0001287605,0.00004936575,0.000146815,0.00009845605,0.00008383554,0.0005777702,0.000003028908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914533,0.004585012,0.0005829678,0.0002225396,0.00003143285,0.000009593811,0.002218367,0.00001356414,0.00088329],"genre_scores_gemma":[0.9975353,0.000641951,0.0002324307,0.0001292086,0.00002307776,0.00001263193,0.001161272,0.000006517382,0.0002575297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00761435,"threshold_uncertainty_score":0.01514006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007218805349479216,"score_gpt":0.2539430297534279,"score_spread":0.2467242244039487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}