{"id":"W4407190420","doi":"10.1093/ndt/gfae216","title":"Upcoming drug targets for kidney protective effects in chronic kidney disease","year":2024,"lang":"en","type":"review","venue":"Nephrology Dialysis Transplantation","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Department of Medicine, Georgetown University; Astellas Pharma; University of Toronto; Sanofi; Kidney Foundation of Canada; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Canadian Society of Nephrology; Diabetes Canada; Novo Nordisk; Bayer","keywords":"Medicine; Kidney disease; Intensive care medicine; Cardiorenal syndrome; Kidney; Diabetes mellitus; Internal medicine; Disease; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007665787,0.0005576175,0.0009390581,0.0009827436,0.0003257347,0.00138732,0.000723154,0.001922057,0.02893741],"category_scores_gemma":[0.00141822,0.0001751714,0.001161213,0.0006372372,0.0002490907,0.001452409,0.0007982038,0.003248739,0.007274645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005882439,"about_ca_system_score_gemma":0.001302824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009032256,"about_ca_topic_score_gemma":0.003625478,"domain_scores_codex":[0.999523,0.0001127067,0.00004931998,0.00005270502,0.0001854585,0.00007687324],"domain_scores_gemma":[0.9992046,0.0002514965,0.0001134558,0.00002542986,0.0002991346,0.0001060435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004154704,0.0002210005,0.0002771335,0.01186974,0.00019457,0.0003168428,0.00008792955,0.0002080797,0.003477551,0.008166872,0.1838736,0.7908912],"study_design_scores_gemma":[0.0001484551,0.0003525322,0.0006330409,0.002565186,0.0001750411,0.0003391186,0.00003936032,0.0001073883,0.0004058767,0.002235304,0.9929804,0.00001824694],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001544652,0.9510999,0.001224035,0.01523549,0.006528356,0.0001328076,0.001004726,0.0002680727,0.02296198],"genre_scores_gemma":[0.01013419,0.9410836,0.002973484,0.01656152,0.004393944,0.0002219953,0.001537045,0.00005263144,0.0230416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02893741,"threshold_uncertainty_score":0.09680527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01990890455821515,"score_gpt":0.3121344376484506,"score_spread":0.2922255330902355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}