{"id":"W4407191091","doi":"10.1080/15548627.2025.2457915","title":"Development and validation of a sensitive sandwich ELISA against human PINK1","year":2025,"lang":"en","type":"article","venue":"Autophagy","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Institute of Aging; National Institutes of Health; Congressionally Directed Medical Research Programs; Mayo Clinic; Michael J. Fox Foundation for Parkinson's Research; U.S. Department of Defense","keywords":"Biology; PINK1; Cell biology; Autophagy; Computational biology; Mitophagy; Genetics; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00442413,0.002047596,0.0009697117,0.001238538,0.0004091714,0.0008218497,0.001498225,0.001560534,0.0007772216],"category_scores_gemma":[0.003258428,0.0007730394,0.0008961171,0.0005787517,0.0006502012,0.00058737,0.00124636,0.001724955,0.001241732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005587491,"about_ca_system_score_gemma":0.001000003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004267376,"about_ca_topic_score_gemma":0.0006203419,"domain_scores_codex":[0.9951793,0.00131727,0.0003476761,0.0009930787,0.001862483,0.0003001632],"domain_scores_gemma":[0.9984919,0.0004240687,0.0001981092,0.0002358284,0.0004912372,0.0001589433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007782839,0.0001386436,0.0007048557,0.0001173902,0.00003521267,0.00005051063,0.000068168,0.0005589897,0.989994,0.0002372269,0.0001982738,0.007819041],"study_design_scores_gemma":[0.00003759766,0.0009457472,0.002237687,0.00003691388,0.00006933997,0.0004729566,0.00006170696,0.01439407,0.9773826,0.0003123802,0.003999542,0.00004948223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2325126,0.003102003,0.7547684,0.0005343948,0.0004220327,0.001803486,0.0009973804,0.003193815,0.002665924],"genre_scores_gemma":[0.4263523,0.002079921,0.5594321,0.000699127,0.0001267793,0.002312487,0.002289174,0.0001525787,0.006555529],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00442413,"threshold_uncertainty_score":0.02339727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008311124158508916,"score_gpt":0.2482983433339963,"score_spread":0.2399872191754874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}