{"id":"W4407191091","doi":"10.1080/15548627.2025.2457915","title":"Development and validation of a sensitive sandwich ELISA against human PINK1","year":2025,"lang":"en","type":"article","venue":"Autophagy","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Institute of Aging; National Institutes of Health; Congressionally Directed Medical Research Programs; Mayo Clinic; Michael J. Fox Foundation for Parkinson's Research; U.S. Department of Defense","keywords":"Biology; PINK1; Cell biology; Autophagy; Computational biology; Mitophagy; Genetics; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000641766,0.00008857912,0.00008841338,0.00004468044,0.00006832546,0.000009072199,0.00005300505,0.00005739218,0.000003488384],"category_scores_gemma":[0.00001417317,0.00009220136,0.00002115743,0.00006303546,0.00004105003,0.000001378846,0.00009838265,0.00002856932,0.000001525581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006400822,"about_ca_system_score_gemma":0.00006555109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004996895,"about_ca_topic_score_gemma":0.00001146272,"domain_scores_codex":[0.9994566,0.00001939102,0.000159729,0.0002009095,0.00006035909,0.0001030567],"domain_scores_gemma":[0.9997802,0.000003970241,0.00004251127,0.0001063398,0.00004284866,0.00002406807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001022142,0.00003239023,0.0006974968,0.00001901799,0.00003888312,9.563298e-7,0.0001379559,0.0000137673,0.9911836,0.000202623,0.0002685254,0.00739458],"study_design_scores_gemma":[0.0003402924,0.00002901806,0.07327332,0.00001447043,0.000005091091,8.569316e-7,0.00006994688,0.000009371358,0.916536,0.00004850096,0.009588851,0.00008424034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951426,0.0002282179,0.0002649394,0.00003593859,0.00005443667,0.0001034748,0.000003142322,0.000005605087,0.004161687],"genre_scores_gemma":[0.9975562,0.00009921693,0.001324377,0.0003032598,0.000004936046,0.000007993629,0.00008811454,0.000006717866,0.0006091804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07464755,"threshold_uncertainty_score":0.3759862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008311124158508916,"score_gpt":0.2482983433339963,"score_spread":0.2399872191754874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}