{"id":"W4407192173","doi":"10.3390/curroncol32020090","title":"Causative Genes of Homologous Recombination Deficiency (HRD)-Related Breast Cancer and Specific Strategies at Present","year":2025,"lang":"en","type":"review","venue":"Current Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PALB2; Homologous recombination; Medicine; CHEK2; Breast cancer; Homologous chromosome; Cancer; Gene; Synthetic lethality; DNA repair; Genetics; Cancer research; Bioinformatics; Internal medicine; Mutation; Germline mutation; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004206675,0.0005612372,0.0006167464,0.001878191,0.0003550448,0.0006682102,0.0005053518,0.0008344825,0.003881629],"category_scores_gemma":[0.0006770148,0.0002149884,0.00067107,0.001352886,0.0005140043,0.0007959267,0.0005008202,0.0009913377,0.0009571093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007452083,"about_ca_system_score_gemma":0.0008403907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001322775,"about_ca_topic_score_gemma":0.001409611,"domain_scores_codex":[0.9996821,0.00005759224,0.0000432969,0.00009678047,0.00008019703,0.00004015027],"domain_scores_gemma":[0.9997815,0.00006760332,0.00006558828,0.00001489572,0.00004091801,0.00002953032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005434869,0.0001874149,0.05102085,0.006746716,0.0002808483,0.01493298,0.0003495552,0.0006138934,0.02538864,0.01970373,0.03520113,0.8450307],"study_design_scores_gemma":[0.00007111477,0.0003158416,0.08642708,0.002859022,0.001013406,0.1725305,0.0007792398,0.0008209737,0.0178352,0.02122329,0.6959884,0.0001358746],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01185828,0.9696465,0.004989125,0.004612966,0.0004598968,0.0000349414,0.0004517226,0.00009305275,0.007853443],"genre_scores_gemma":[0.08868545,0.8911649,0.007603373,0.002176376,0.001053597,0.00006960946,0.00131289,0.00003688493,0.00789695],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003881629,"threshold_uncertainty_score":0.01298535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07040119303398928,"score_gpt":0.4160197626561489,"score_spread":0.3456185696221596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}