{"id":"W4407194247","doi":"10.1016/j.stemcr.2025.102406","title":"20 years of stemness: From stem cells to hypertranscription and back","year":2025,"lang":"en","type":"review","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Biology; Stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003891829,0.0004286304,0.001288337,0.0002005407,0.00003865825,0.00004385538,0.0003004807,0.0005834848,0.00005289609],"category_scores_gemma":[0.000005976639,0.0004171847,0.0003963142,0.000226971,0.0000620998,0.000004838727,0.0003525404,0.000206157,0.00007352509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004537419,"about_ca_system_score_gemma":0.0004604974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005945598,"about_ca_topic_score_gemma":0.00001551296,"domain_scores_codex":[0.9968342,0.0002430121,0.001047462,0.001092562,0.0004029729,0.000379847],"domain_scores_gemma":[0.9979922,0.00006797365,0.0004703111,0.001123458,0.000127829,0.0002182031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004669228,0.0001294279,0.00004686042,0.04120754,0.0004282976,0.0004391088,0.00007140306,0.000009717412,0.08082101,0.000001411765,0.008669064,0.8681295],"study_design_scores_gemma":[0.0001237217,0.0001128055,0.000005145356,0.004064687,0.0002757917,0.0000435447,0.00002841179,5.742629e-7,0.02810617,0.000001870585,0.9668823,0.0003549974],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004458396,0.9902119,0.0001059619,0.000006804514,0.0006240617,0.001440635,0.0002721331,0.00001208976,0.002867989],"genre_scores_gemma":[0.0006712303,0.9616202,0.000150442,0.00002341426,0.0001172786,0.00007846299,0.0003196123,0.00006690963,0.03695252],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9582132,"threshold_uncertainty_score":0.999828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0237226250090526,"score_gpt":0.2793959458893255,"score_spread":0.2556733208802729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}