{"id":"W4407209120","doi":"10.1111/add.16772","title":"Evaluating mediators of the effect of varenicline preloading on smoking abstinence in a randomized controlled trial","year":2025,"lang":"en","type":"article","venue":"Addiction","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mental Health Research Canada; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research; Canada Research Chairs; National Center for Advancing Translational Sciences; Division of Cancer Prevention, National Cancer Institute","keywords":"Varenicline; Abstinence; Smoking cessation; Randomized controlled trial; Placebo; Medicine; Craving; Psychology; Nicotine; Psychiatry; Internal medicine; Addiction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00331393,0.00008544802,0.00076363,0.0001978623,0.00003350228,0.000003101288,0.00004878016,0.00008157273,0.00003434472],"category_scores_gemma":[0.006266169,0.00004946142,0.0002471161,0.0003450793,0.00004725418,0.00002741996,0.00001329262,0.0001655798,1.397887e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007419051,"about_ca_system_score_gemma":0.00006574632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006412542,"about_ca_topic_score_gemma":0.000002454009,"domain_scores_codex":[0.9983212,0.0004960765,0.000623017,0.0001234357,0.0003572371,0.00007905209],"domain_scores_gemma":[0.9973567,0.002038848,0.0003652427,0.0001595511,0.00006734953,0.00001228748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.912406,0.00007234883,0.07170473,0.00005017575,0.0001189124,3.531777e-7,0.0001715985,0.0003426898,0.005756196,0.00006368034,0.0000114162,0.009301941],"study_design_scores_gemma":[0.9107611,0.0005752651,0.04454522,0.001038802,0.001035499,4.988112e-7,0.00001503157,0.003793739,0.0381714,0.00003074434,0.00000128333,0.00003137732],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953344,0.0000639608,0.00008193164,0.00007290862,0.0009417438,0.002826545,0.000001062566,0.00001752583,0.0006598863],"genre_scores_gemma":[0.9995391,0.000008677281,0.00001102863,0.00001803608,0.00005890938,0.000300145,0.000005982359,0.000005216262,0.00005295681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0324152,"threshold_uncertainty_score":0.7501642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0169084124614732,"score_gpt":0.3503023643195933,"score_spread":0.33339395185812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}