{"id":"W4407209595","doi":"10.4046/trd.2024.0198","title":"International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update","year":2025,"lang":"en","type":"article","venue":"Tuberculosis & respiratory diseases","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"Medical Research Council; Kuwait Foundation for the Advancement of Sciences; Incyte; Cerecor; Shionogi; Daiichi Sankyo Europe; Sanofi; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; Genentech; AstraZeneca; GlaxoSmithKline; Novartis Pharmaceuticals UK Limited; Amgen","keywords":"Asthma; Medicine; Referral; Clinical trial; Medical emergency; Intensive care medicine; Family medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02705991,0.001603828,0.002751247,0.01076295,0.001338242,0.007304835,0.004271103,0.003740678,0.02014937],"category_scores_gemma":[0.04509308,0.000976724,0.002741654,0.01237151,0.0009934769,0.008639071,0.006578575,0.004541145,0.01644268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004926913,"about_ca_system_score_gemma":0.02747928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02273489,"about_ca_topic_score_gemma":0.01525396,"domain_scores_codex":[0.9900162,0.001649898,0.002467698,0.0007638488,0.00391256,0.001189903],"domain_scores_gemma":[0.9545723,0.007038218,0.006239841,0.001379839,0.02521265,0.005557103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003265329,0.0001047096,0.009623805,0.003608055,0.000176565,0.00009097382,0.0001414726,0.0005069515,0.000126645,0.003991403,0.7608619,0.220441],"study_design_scores_gemma":[0.0001071248,0.00008435263,0.01191995,0.007350884,0.0002077036,0.0001919107,0.0001830919,0.0003933963,0.00023519,0.001026239,0.9782447,0.00005546656],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"other","genre_scores_codex":[0.009509433,0.2671762,0.01227824,0.1674645,0.05015888,0.00205303,0.4007745,0.00641497,0.08417011],"genre_scores_gemma":[0.02708412,0.1827,0.0185864,0.02604968,0.0130612,0.003798744,0.7106328,0.001156688,0.01693035],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.02705991,"threshold_uncertainty_score":0.1431081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009420957473259906,"score_gpt":0.2912218367143923,"score_spread":0.2818008792411325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}