{"id":"W4407209595","doi":"10.4046/trd.2024.0198","title":"International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update","year":2025,"lang":"en","type":"article","venue":"Tuberculosis & respiratory diseases","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"Medical Research Council; Kuwait Foundation for the Advancement of Sciences; Incyte; Cerecor; Shionogi; Daiichi Sankyo Europe; Sanofi; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; Genentech; AstraZeneca; GlaxoSmithKline; Novartis Pharmaceuticals UK Limited; Amgen","keywords":"Asthma; Medicine; Referral; Clinical trial; Medical emergency; Intensive care medicine; Family medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001228232,0.0004341027,0.0005221399,0.0003867276,0.0002602663,0.0001654434,0.0002633778,0.0001788221,0.0008259441],"category_scores_gemma":[0.0002402398,0.0003745433,0.000286308,0.0004069406,0.0005466046,0.0003103073,0.0002768856,0.0002857494,0.0001157947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001651775,"about_ca_system_score_gemma":0.0005479766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001357197,"about_ca_topic_score_gemma":0.000006058784,"domain_scores_codex":[0.9973744,0.0001343099,0.000531319,0.0008065288,0.0005867974,0.0005666203],"domain_scores_gemma":[0.9980007,0.00008143847,0.0001555708,0.0007528993,0.0002713568,0.0007379813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009163535,0.0008709615,0.7573171,0.0007154343,0.0005506258,0.0004650283,0.0000571746,0.000008160224,0.0003033282,0.0005899943,0.1080149,0.130191],"study_design_scores_gemma":[0.001548218,0.0001319606,0.4255283,0.000387339,0.0003640952,0.00002332698,0.0002060252,0.0000436657,0.0001594675,0.000108219,0.5712023,0.0002970109],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9408928,0.04122949,0.00001647327,0.002459571,0.0008663852,0.0007791765,0.0005681216,0.0003340206,0.01285393],"genre_scores_gemma":[0.9866377,0.0009416417,0.0001283852,0.008609468,0.0005676072,0.0002171774,0.0001744529,0.00006115551,0.00266238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4631874,"threshold_uncertainty_score":0.9998707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009420957473259906,"score_gpt":0.2912218367143923,"score_spread":0.2818008792411325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}