{"id":"W4407219929","doi":"10.1089/nat.2024.0072","title":"Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations","year":2025,"lang":"en","type":"review","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics","funders":"Alnylam Pharmaceuticals; Silence Therapeutics; AstraZeneca","keywords":"Oligonucleotide; Computational biology; Risk analysis (engineering); Business; Computer science; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0363786,0.002188897,0.001374197,0.007053973,0.001205587,0.003678386,0.005315084,0.007094181,0.006928092],"category_scores_gemma":[0.05114595,0.001218501,0.002616703,0.002891803,0.001832063,0.003888638,0.002762921,0.006129009,0.005951662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002599641,"about_ca_system_score_gemma":0.01019337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008053531,"about_ca_topic_score_gemma":0.01073895,"domain_scores_codex":[0.9704992,0.007731157,0.004691411,0.001183763,0.0150242,0.0008702646],"domain_scores_gemma":[0.9246005,0.02240268,0.006845081,0.003771463,0.04090664,0.001473696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003034489,0.0006427767,0.003253708,0.004773017,0.0001755134,0.000508976,0.000511907,0.00729527,0.0196146,0.01567487,0.1839441,0.7633018],"study_design_scores_gemma":[0.00007449021,0.000601361,0.004026407,0.005421524,0.000418366,0.0009721671,0.0004146798,0.005418767,0.02298543,0.01691729,0.9425485,0.0002009631],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.02183777,0.2460567,0.3679751,0.1880029,0.009730121,0.003789181,0.01155996,0.006203781,0.1448445],"genre_scores_gemma":[0.07025857,0.224383,0.5760912,0.05609529,0.003388271,0.003922825,0.0125099,0.0013578,0.05199308],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0363786,"threshold_uncertainty_score":0.1923907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04980270846630515,"score_gpt":0.3626995612161958,"score_spread":0.3128968527498907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}