{"id":"W4407224243","doi":"10.1002/mds.30144","title":"Effects of Montelukast on Neuroinflammation in Parkinson's Disease: An Open Label Safety and Tolerability Trial with <scp>CSF</scp> Markers and [<scp><sup>11</sup>C</scp>]<scp>PBR28 PET</scp>","year":2025,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H. Lundbeck A/S; Vetenskapsrådet; Karolinska Institutet; Knut och Alice Wallenbergs Stiftelse; Kommunfullmäktige, Stockholms Stad","keywords":"Montelukast; Tolerability; Neuroinflammation; Parkinson's disease; Internal medicine; Medicine; Adverse effect; Leukotriene receptor; Gastroenterology; Disease; Asthma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006550565,0.0006886074,0.001022832,0.0004070762,0.0002570589,0.0001719591,0.0003198697,0.0001418997,0.000007231914],"category_scores_gemma":[0.001179804,0.0005998265,0.0001117645,0.0005462434,0.0002192697,0.0004873257,0.0002993155,0.000296365,0.000003609253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002383192,"about_ca_system_score_gemma":0.0002726193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005875025,"about_ca_topic_score_gemma":0.0005914957,"domain_scores_codex":[0.9960576,0.0004454945,0.0007646055,0.00128004,0.0007278436,0.0007244726],"domain_scores_gemma":[0.997034,0.00115593,0.0003394262,0.0007726534,0.0001061356,0.0005918586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01987748,0.01875105,0.9105838,0.003851286,0.001624753,0.0006499637,0.002721866,0.001175211,0.001394726,0.002807703,0.00417576,0.03238642],"study_design_scores_gemma":[0.09963037,0.004512786,0.8663268,0.0008031811,0.0007572086,0.0000012179,0.002176559,0.006628911,0.0008549053,0.003406243,0.01477453,0.0001272966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894398,0.0008526894,0.0001759401,0.0004692664,0.0001429888,0.006356015,0.0001571107,0.00008854611,0.002317664],"genre_scores_gemma":[0.9953333,0.0009601284,0.0003018329,0.001126769,0.00004496157,0.0006560797,0.0002509888,0.00007782514,0.00124809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07975288,"threshold_uncertainty_score":0.9996453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009488743697241541,"score_gpt":0.2540247914390028,"score_spread":0.2445360477417613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}