{"id":"W4407224243","doi":"10.1002/mds.30144","title":"Effects of Montelukast on Neuroinflammation in Parkinson's Disease: An Open Label Safety and Tolerability Trial with <scp>CSF</scp> Markers and [<scp><sup>11</sup>C</scp>]<scp>PBR28 PET</scp>","year":2025,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H. Lundbeck A/S; Vetenskapsrådet; Karolinska Institutet; Knut och Alice Wallenbergs Stiftelse; Kommunfullmäktige, Stockholms Stad","keywords":"Montelukast; Tolerability; Neuroinflammation; Parkinson's disease; Internal medicine; Medicine; Adverse effect; Leukotriene receptor; Gastroenterology; Disease; Asthma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001429122,0.0009046394,0.001828514,0.0002648987,0.0003358717,0.0007073972,0.0004656705,0.001212301,0.001592861],"category_scores_gemma":[0.001125744,0.0003776536,0.001005328,0.0002219748,0.0009656441,0.0008383935,0.0002446899,0.001536474,0.0003253452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004641276,"about_ca_system_score_gemma":0.0006258189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004297159,"about_ca_topic_score_gemma":0.0009171737,"domain_scores_codex":[0.9994906,0.000235716,0.00004864939,0.00008797226,0.00005344104,0.00008357254],"domain_scores_gemma":[0.9991769,0.0002035908,0.0001812961,0.0000633708,0.00006506084,0.0003097489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8937594,0.02437629,0.00279431,0.0004970487,0.000777777,0.0001505963,0.0002292471,0.0006554531,0.03778419,0.0001131113,0.0003753568,0.03848723],"study_design_scores_gemma":[0.3632543,0.6138336,0.01458764,0.00003598832,0.0004970473,0.0002010532,0.00006380551,0.001060738,0.005596106,0.0001127947,0.0007247937,0.00003215281],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997779,0.001030789,0.0001927737,0.00007053368,0.00003242898,0.0004274491,0.0001613075,0.00002495863,0.0002806738],"genre_scores_gemma":[0.9979615,0.0004599897,0.0004177661,0.0001126814,0.00006374143,0.0003977272,0.0002074457,0.00000580237,0.0003732576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001828514,"threshold_uncertainty_score":0.007558048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009488743697241541,"score_gpt":0.2540247914390028,"score_spread":0.2445360477417613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}