{"id":"W4407226137","doi":"10.1099/acmi.0.000925.v2","title":"Immunogenicity of virus-like particle vaccine candidates against SARS-CoV-2 infection","year":2025,"lang":"en","type":"preprint","venue":"","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Immunogenicity; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Virus-like particle; Virus; Medicine; Biology; Immunology; Antigen; Infectious disease (medical specialty); Outbreak; Disease; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002491914,0.0002713985,0.000252797,0.0001640795,0.00008366979,0.0003136,0.0001630889,0.0003738937,0.0009855382],"category_scores_gemma":[0.000289464,0.00008522988,0.0002074613,0.00009652021,0.0001150494,0.0002177353,0.0001651782,0.0004213089,0.0002934951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000166605,"about_ca_system_score_gemma":0.0001274972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002071771,"about_ca_topic_score_gemma":0.0001656286,"domain_scores_codex":[0.9998971,0.00002369651,0.000006977393,0.00001592955,0.00002441936,0.00003183124],"domain_scores_gemma":[0.9999197,0.0000171492,0.00001563014,0.000008177992,0.00001649072,0.00002295229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002604224,0.0001029961,0.0005864329,0.0000323593,0.0000109159,0.00004411895,0.00001711467,0.00035986,0.9966286,0.00007017414,0.00005383661,0.001833222],"study_design_scores_gemma":[0.0001312324,0.006545429,0.01159571,0.00001910595,0.00005533674,0.0004640253,0.00006315148,0.003143564,0.974443,0.000154592,0.003374419,0.0000104549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981431,0.000370825,0.0008369623,0.00004123481,0.00001690115,0.00002435491,0.00007739908,0.00001347715,0.0004757879],"genre_scores_gemma":[0.9974267,0.0002125474,0.0009104956,0.00005144467,0.00001414425,0.00002068266,0.0005093263,0.000006985131,0.0008476621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009855382,"threshold_uncertainty_score":0.003296912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04297496320681152,"score_gpt":0.3629174527777054,"score_spread":0.3199424895708939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}