{"id":"W4407226825","doi":"10.1101/2025.01.31.635552","title":"Humanized Bone Marrow-Liver-Thymus Mice for Studying HIV-1 Persistence in Liver and Lung CD4+ T and Myeloid Cell Subsets during Antiretroviral Therapy","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Centre Hospitalier Universitaire Sainte-Justine; Centre hospitalier de l'Université Laval; Montreal Clinical Research Institute; Université Laval; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Antiretroviral therapy; Persistence (discontinuity); Immunology; Lung; Bone marrow; Human immunodeficiency virus (HIV); Myeloid; Medicine; Myeloid cells; Biology; Viral load; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004387999,0.0005866261,0.0003237283,0.001022618,0.0004009584,0.0005039921,0.0004434469,0.0007700888,0.005430084],"category_scores_gemma":[0.0001081268,0.0003108137,0.0003711761,0.0003598464,0.0003881754,0.0003746315,0.0003217769,0.001226304,0.001106933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003028538,"about_ca_system_score_gemma":0.0002287303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005361226,"about_ca_topic_score_gemma":0.0009325538,"domain_scores_codex":[0.9995729,0.00007865289,0.0000431703,0.0001235198,0.00008002441,0.0001016933],"domain_scores_gemma":[0.9997883,0.00002415923,0.00005676366,0.0000336954,0.00002053984,0.00007660569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007899721,0.0002367888,0.0005282205,0.00006649672,0.000008437808,0.0001006227,0.00005370535,0.00006608712,0.9958705,0.0002347349,0.00008534067,0.00195907],"study_design_scores_gemma":[0.000169696,0.002276813,0.008746707,0.0000411024,0.00005482199,0.001172394,0.0001513615,0.00100881,0.980209,0.0001862847,0.005968226,0.00001489346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735447,0.00419987,0.01145616,0.0002798931,0.0001294791,0.0007722084,0.005097833,0.00032717,0.004192685],"genre_scores_gemma":[0.964933,0.001834917,0.01839339,0.0002381899,0.00003983568,0.0010137,0.002749674,0.00008436022,0.01071311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005430084,"threshold_uncertainty_score":0.01816541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02202242667515882,"score_gpt":0.250598261419847,"score_spread":0.2285758347446881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}