{"id":"W4407228866","doi":"10.3389/fmolb.2025.1548582","title":"Distinct roles of Constitutive Photomorphogenesis Protein 1 homolog (COP1) in human hepatocyte models","year":2025,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Skin Protection and Aging","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Heart Research Centre; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Photomorphogenesis; Biology; Gene silencing; Cell biology; Transcriptome; Transcription factor; Hepatocyte; Molecular biology; Gene expression; Genetics; Gene; Arabidopsis; Mutant; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003278223,0.000125557,0.000313462,0.0006098445,0.00007037407,0.00001471435,0.0001836912,0.00007901344,0.000008294362],"category_scores_gemma":[0.0001516964,0.0001120702,0.00006852759,0.001074538,0.0006844287,0.00006968851,0.00004630521,0.0001370549,4.148675e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009604132,"about_ca_system_score_gemma":0.0002556999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003638875,"about_ca_topic_score_gemma":0.00009868648,"domain_scores_codex":[0.9988245,0.00008181705,0.0003021362,0.0003454084,0.0002198117,0.0002262861],"domain_scores_gemma":[0.9996248,0.000009154631,0.00008196615,0.0001806447,0.0000477717,0.00005569029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001673684,0.0003292939,0.2829162,0.0001659789,0.00004792825,0.0003224648,0.0004008466,0.0002814178,0.7050986,0.005227926,0.0003211939,0.004720722],"study_design_scores_gemma":[0.001565575,0.0001491987,0.01383509,0.0009459627,0.00003047064,0.000008828893,0.001281667,0.009307308,0.9621409,0.01025323,0.0002695604,0.0002122745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9299946,0.000966982,0.06415831,0.0002985141,0.0002158963,0.0007974752,0.000008286699,0.00002462296,0.003535268],"genre_scores_gemma":[0.9906621,0.0000138307,0.008870594,0.0001884505,0.000004565375,0.00009266645,0.000003269067,0.000004701323,0.0001598467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2690812,"threshold_uncertainty_score":0.4570091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104058584555956,"score_gpt":0.2656477236869724,"score_spread":0.2546071378414128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}